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Anticancerogenic effect of a novel chiroinositol-containing polysaccharide from Bifidobacterium bifidum BGN4
Cited 52 time in
Web of Science
Cited 58 time in Scopus
- Authors
- Issue Date
- 2004-11
- Publisher
- Blackwell
- Citation
- FEMS Microbiology Letters, Vol.240 No.2, pp.131-136
- Abstract
- Strains of bifidobacteria have many health-promotion effects. Whole cells or cytoplasm extracts of Bifidobacterium bifidum BGN4, isolated from human feces, inhibited the growth of several cancer cell lines. The polysaccharide fraction (BB-pol) extracted from B. bifidum BGN4 had a novel composition, comprising chiroinositol, rhamnose, glucose, galactose, and ribose. Three human colon cancer cell lines were treated with BB-pol: HT-29, HCT-116, and Caco-2. Trypan blue exclusion assay and BrdU incorporation assay showed that BB-pol inhibited the growth of HT-29 and HCT-116 cells but did not inhibit the growth of Caco-2 cells. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
- ISSN
- 0378-1097
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