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Osteogenic responses to zirconia with hydroxyapatite coating by aerosol deposition

Cited 53 time in Web of Science Cited 52 time in Scopus
Authors

Cho, Y.; Hong, J.; Ryoo, H.; Kim, D.; Park, J.; Han, J.

Issue Date
2015-03
Publisher
SAGE Publications
Citation
Journal of Dental Research, Vol.94 No.3, pp.491-499
Abstract
Previously, we found that osteogenic responses to zirconia co-doped with niobium oxide (Nb2O5) or tantalum oxide (Ta2O5) are comparable with responses to titanium, which is widely used as a dental implant material. The present study aimed to evaluate the in vitro osteogenic potential of hydroxyapatite (HA)-coated zirconia by an aerosol deposition method for improved osseointegration. Surface analysis by scanning electron microscopy and x-ray diffraction proved that a thin as-deposited HA film on zirconia showed a shallow, regular, crater-like surface. Deposition of dense and uniform HA films was measured by SEM, and the contact angle test demonstrated improved wettability of the HA-coated surface. Confocal laser scanning microscopy indicated that MC3T3-E1 pre-osteoblast attachment did not differ notably between the titanium and zirconia surfaces; however, cells on the HA-coated zirconia exhibited a lower proliferation than those on the uncoated zirconia late in the culture. Nevertheless, ALP, alizarin red S staining, and bone marker gene expression analysis indicated good osteogenic responses on HA-coated zirconia. Our results suggest that HA-coating by aerosol deposition improves the quality of surface modification and is favorable to osteogenesis.
ISSN
0022-0345
URI
https://hdl.handle.net/10371/200653
DOI
https://doi.org/10.1177/0022034514566432
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Cho, Young-Dan Image

Cho, Young-Dan조영단
(기금)조교수
  • School of Dentistry
  • Department of Dentistry
Research Area Alveolar bone regeneration, Dental implant surface modification, Periomics

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