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Design and Implementation of an On-Chip Patient-Specific Closed-Loop Seizure Onset and Termination Detection System
Cited 25 time in
Web of Science
Cited 30 time in Scopus
- Authors
- Issue Date
- 2016-07
- Citation
- IEEE Journal of Biomedical and Health Informatics, Vol.20 No.4, pp.996-1007
- Abstract
- This paper presents the design of an area-and energy-efficient closed-loop machine learning-based patient-specific seizure onset and termination detection algorithm, and its on-chip hardware implementation. Application-and scenario-based tradeoffs are compared and reviewed for seizure detection and suppression algorithm and system which comprises electroencephalography (EEG) data acquisition, feature extraction, classification, and stimulation. Support vector machine achieves a good tradeoff among power, area, patient specificity, latency, and classification accuracy for long-term monitoring of patients with limited training seizure patterns. Design challenges of EEG data acquisition on a multichannel wearable environment for a patch-type sensor are also discussed in detail. Dual-detector architecture incorporates two area-efficient linear support vector machine classifiers along with a weight-and-average algorithm to target high sensitivity and good specificity at once. On-chip implementation issues for a patient-specific transcranial electrical stimulation are also discussed. The system design is verified using CHB-MIT EEG database [1] with a comprehensive measurement criteria which achieves high sensitivity and specificity of 95.1% and 96.2%, respectively, with a small latency of 1 s. It also achieves seizure onset and termination detection delay of 2.98 and 3.82 s, respectively, with seizure length estimation error of 4.07 s.
- ISSN
- 2168-2194
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Related Researcher
- College of Engineering
- Department of Electrical and Computer Engineering
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