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Discovery of penta-peptides inhibiting activity of formylglycine generating enzyme and its potential antibacterial effect against Mycobacterium tuberculosis : The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against <i>Mycobacterium tuberculosis</i>
Cited 1 time in
Web of Science
Cited 1 time in Scopus
- Authors
- Issue Date
- 2022-06
- Publisher
- Royal Society of Chemistry
- Citation
- RSC Advances, Vol.12 No.29, pp.18884-18888
- Abstract
- The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model.
- ISSN
- 2046-2069
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Related Researcher
- Graduate School of Convergence Science & Technology
- Dept. of Molecular and Biopharmaceutical Sciences
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