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Hb-adjusted DLCO with GLI reference predicts long-term survival after HSCT in children

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors

Lee, Hye Jin; Kim, Kyunghoon; Kim, Seong Koo; Lee, Jae Wook; Yoon, Jong-seo; Chung, Nack-Gyun; Bin, Cho

Issue Date
2021-08
Publisher
Nature Publishing Group
Citation
Bone Marrow Transplantation, Vol.56 No.8, pp.1929-1936
Abstract
This study aimed to evaluate the pretransplant diffusing capacity as a predictor of outcomes in pediatric allogeneic hematopoietic stem cell transplantation (allo-HSCT). Retrospective cohort study of 176 children followed outcomes for 5 years after allo-HSCT. We conducted an analysis of PFTs include spirometry, body plethysmography, and diffusing capacity prior to allo-HSCT. We analyzed the probabilities of overall survival (OS), disease-related mortality (DRM), and non-relapse mortality (NRM). Of all carbon monoxide diffusing capacity (DLCO) parameters obtained using the Global Lung Function Initiative (GLI)-2017, univariate analysis showed that the grade 3, 4 of DLCOadj and Category III, IV of LFS significantly increase NRM (p = 0.003 and p = 0.008). Multivariate analysis indicated that a significant increase in the risk of NRM is associated with grades 3, 4 DLCOadj (hazard ratio [HR] = 4.90, p = 0.020). Kaplan-Meier analyses showed that a significant stepwise increase in NRM was observed with both worse pretransplant DLCOadj grades and LFS categories (p < 0.001 and p = 0.003). A compromised pretransplant diffusing capacity and a high LFS significantly increase the risk of NRM. Especially, DLCOadj before transplantation can be used as an important predictor of NRM after allo-HSCT in children with malignancy.
ISSN
0268-3369
URI
https://hdl.handle.net/10371/201606
DOI
https://doi.org/10.1038/s41409-020-01202-9
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  • College of Medicine
  • Department of Medicine
Research Area 식품알레르기, 아토피피부염, 천식

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