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Safety and efficacy of early high parenteral lipid supplementation in preterm infants: A systematic review and meta-analysis

Cited 6 time in Web of Science Cited 9 time in Scopus

Kim, Kyunghoon; Kim, Na Jin; Kim, Sae Yun

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Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients, Vol.13 No.5, p. 1535
The objective of this systematic review and meta-analysis was to summarize the effects of early initiation and achievement of a high dose of parenteral lipids (>= 1.5 g/kg/day reached within the first 24 h of birth) on growth and adverse outcomes in preterm infants. PubMed, EMBASE, and Cochrane databases were utilized to search for publications for this meta-analysis. Randomized controlled trials were eligible if data on growth or clinical outcome was available. The search returned nine studies. The mean proportion of postnatal weight loss (%) was lower (mean difference [MD]: -2.73; 95% confidence interval [CI]: -3.69, -1.78), and the mean head circumference near the term equivalent age (cm) was higher in the early high lipid treatment group (MD: 0.67; 95% CI: 0.25, 1.09). There was a favorable association of early high lipid administration with the incidence of extrauterine growth restriction (relative risk [RR]: 0.27; 95% CI: 0.15, 0.48). Generally, there were no differences in morbidities or adverse outcomes with early high lipid administration. Early initiation of parenteral lipids and high dose achieved within the first 24 h of life appear to be safe and endurable and offer benefits in terms of growth.
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  • College of Medicine
  • Department of Medicine
Research Area 식품알레르기, 아토피피부염, 천식


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