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Identifying long-term survival candidates among patients with isolated locoregionally recurrent breast cancer: Implications of the use of systemic chemotherapy

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Kim, Byoung Hyuck; Shin, Kyung Hwan; Chie, Eui Kyu; Kim, Jin Ho; Kim, Kyubo; Hwang, Ki-Tae; Kim, Jongjin; Choi, In Sil; Park, Jin Hyun; Kim, Suzy

Issue Date
Journal of Breast Cancer, Vol.23 No.3, pp.279-290
Purpose: We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods: We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results: Fifty-two (41.6%) patients experienced secondary recurrence or disease progression, of which 20 (38.5%) experienced a secondary locoregional recurrence and 40 (76.9%) experienced DM as the first site of failure. In multivariate analysis of distant metastasis free survival (DMFS) and post-recurrence OS, the initial pN2-3 stage, a disease-free interval of < 36 months, and non-curative resection for recurrent disease were independently poor prognosticators. The score for patients stratified according to the number of risk factors increased from 0 to 3; the corresponding 5-year DMFS rates were 91.4%, 53.0%, 35.9%, and 0% and the 5-year OS rates were 97.3%, 70.4%, 32.7%, and 25.0%, respectively (p < 0.001). Systemic chemotherapy reduced DM in patients with a score of 2-3, but it did not in those with a score of 0-1. Conclusion: Our collective stratification can help with prognosis prediction for ILRR of breast cancer. Depending on the DM risk of patients, the potential combination of systemic therapy should be discussed further.
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Kim, Byoung hyuck김병혁
  • College of Medicine
  • Department of Medicine
Research Area 소화기암, 육종, 폐암


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