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Clinical outcomes of isolated regional lymph node recurrence in patients with malignant cutaneous melanoma

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Kwon, Jeanny; Kim, Young A.; Lee, Cheol; Kim, Byoung Hyuck; Kim, Suzy; Kim, Il Han

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International Institute of Anticancer Research
Anticancer Research, Vol.39 No.6, pp.3147-3157
Background/Aim: Regional lymph node recurrence (RLNR) is the most common pattern of recurrence within 2 years from the diagnosis of patients with non-metastatic malignant cutaneous melanoma. However, isolated RLNR without distant metastasis has been rarely studied. Patients and Methods: Forty patients with isolated RLNR as a first recurrence were analyzed retrospectively. The clinical outcomes and prognostic impact of clinicopathologic parameters were analyzed. Immunostaining for FOXP3, VEGF, pAKT, and pS6 was also performed. Results: The median disease-free interval from first diagnosis to isolated RLNR and post-recurrence recurrence-free survival (pRFS) were 12 months and 7.2 months, respectively. Distant failure was the most common pattern of failure after isolated RLNR (67.5%). The number of initially harvested lymph nodes (LN) >7 and LN ratio >22.2% at the time of recurrence were prognosticators for pRFS in multivariate analysis. None of the tested biomarkers were significantly related to prognosis. The 5-year post-recurrence overall survival rate was 84.9%. Conclusion: Most patients with isolated RLNR will experience a second failure within months, especially distantly. The number of initially harvested LNs and LN ratio at the time of recurrence could predict pRFS.
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Kim, Byoung hyuck김병혁
  • College of Medicine
  • Department of Medicine
Research Area 소화기암, 육종, 폐암


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