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Techniques to Study Automethylation of Histone Methyltransferases and its Functional Impact

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Authors

Popoca, Luis; Lee, Chul-Hwan

Issue Date
2022-01
Publisher
Humana Press, Inc.
Citation
Methods in molecular biology (Clifton, N.J.), Vol.2529, pp.109-120
Abstract
The catalytic activity of histone methyltransferases is not restricted to histones but also includes noncanonical substrates. Increasing evidence shows that histone methyltransferases methylate themselves, and automethylation has emerged as a self-regulatory mechanism. Here, we introduce experimental procedures to identify automethylation sites of histone methyltransferases and to investigate the function of automethylation in a reconstituted biochemical system and in cellular contexts.
ISSN
1064-3745
URI
https://hdl.handle.net/10371/201837
DOI
https://doi.org/10.1007/978-1-0716-2481-4_5
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  • College of Medicine
Research Area Epigenetics, Heterochromatin, Histone Modifications

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