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PRC2 is high maintenance

Cited 154 time in Web of Science Cited 153 time in Scopus
Authors

Yu, Jia-Ray; Lee, Chul-Hwan; Oksuz, Ozgur; Stafford, James M.; Reinberg, Danny

Issue Date
2019-08
Publisher
Cold Spring Harbor Laboratory Press
Citation
Genes and Development, Vol.33 No.15-16, pp.903-935
Abstract
As the process that silences gene expression ensues during development, the stage is set for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene profiles. PRC2 catalyzes a specific histone posttranslational modification (hPTM) that fosters chromatin compaction. PRC2 also facilitates the inheritance of this hPTM through its self-contained "write and read" activities, key to preserving cellular identity during cell division. As these changes in gene expression occur without changes in DNA sequence and are inherited, the process is epigenetic in scope. Mutants of mammalian PRC2 or of its histone substrate contribute to the cancer process and other diseases, and research into these aberrant pathways is yielding viable candidates for therapeutic targeting. The effectiveness of PRC2 hinges on its being recruited to the proper chromatin sites; however, resolving the determinants to this process in the mammalian case was not straightforward and thus piqued the interest of many in the field. Here, we chronicle the latest advances toward exposing mammalian PRC2 and its high maintenance.
ISSN
0890-9369
URI
https://hdl.handle.net/10371/201842
DOI
https://doi.org/10.1101/gad.325050.119
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  • College of Medicine
Research Area Epigenetics, Heterochromatin, Histone Modifications

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