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Iron-Catalyzed Oxidative Cyclization of 2-Amino Styrenes with Alcohols and Methyl Arenes for the Synthesis of Polysubstituted Quinolines
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- Authors
- Issue Date
- 2023-06
- Publisher
- American Chemical Society
- Citation
- The Journal of Organic Chemistry, Vol.7 No.13, pp.820-8113
- Abstract
- Herein, we present the iron-catalyzed oxidative cyclizationofalcohol/methyl arene with 2-amino styrene to synthesize polysubstitutedquinoline. Low-oxidation level substrates such as alcohols and methylarenes are converted to aldehydes in the presence of an iron catalystand di-t-butyl peroxide. Then, the quinoline scaffoldis synthesized through imine condensation/radical cyclization/oxidativearomatization. Our protocol showed a broad substrate scope, and variousfunctionalization and fluorescence applications of quinoline productsdemonstrated its synthetic ability.
- ISSN
- 0022-3263
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