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Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.

Cited 17 time in Web of Science Cited 20 time in Scopus
Authors

An, Joon Soo; Shin, Bora; Kim, Tae Ho; Hwang, Sunghoon; Shin, Yern-Hyerk; Cui, Jinsheng; Du, Young Eun; Yi, Jungwoo; Nam, Sang-Jip; Hong, Suckchang; Shin, Jongheon; Jang, Jichan; Yoon, Yeo Joon; Oh, Dong-Chan

Issue Date
2021-05
Publisher
American Chemical Society
Citation
Organic Letters, Vol.23 No.9, pp.3359-3363
Abstract
Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M).
ISSN
1523-7060
URI
https://hdl.handle.net/10371/201995
DOI
https://doi.org/10.1021/acs.orglett.1c00847
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Development of methodologies using metal catalyst, Total synthesis of natural products

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