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Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | An, Joon Soo | - |
| dc.contributor.author | Shin, Bora | - |
| dc.contributor.author | Kim, Tae Ho | - |
| dc.contributor.author | Hwang, Sunghoon | - |
| dc.contributor.author | Shin, Yern-Hyerk | - |
| dc.contributor.author | Cui, Jinsheng | - |
| dc.contributor.author | Du, Young Eun | - |
| dc.contributor.author | Yi, Jungwoo | - |
| dc.contributor.author | Nam, Sang-Jip | - |
| dc.contributor.author | Hong, Suckchang | - |
| dc.contributor.author | Shin, Jongheon | - |
| dc.contributor.author | Jang, Jichan | - |
| dc.contributor.author | Yoon, Yeo Joon | - |
| dc.contributor.author | Oh, Dong-Chan | - |
| dc.date.accessioned | 2024-05-14T07:16:30Z | - |
| dc.date.available | 2024-05-14T07:16:30Z | - |
| dc.date.created | 2021-06-14 | - |
| dc.date.issued | 2021-05 | - |
| dc.identifier.citation | Organic Letters, Vol.23 No.9, pp.3359-3363 | - |
| dc.identifier.issn | 1523-7060 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/201995 | - |
| dc.description.abstract | Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M). | - |
| dc.language | 영어 | - |
| dc.publisher | American Chemical Society | - |
| dc.title | Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp. | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1021/acs.orglett.1c00847 | - |
| dc.citation.journaltitle | Organic Letters | - |
| dc.identifier.wosid | 000649477300025 | - |
| dc.identifier.scopusid | 2-s2.0-85106162085 | - |
| dc.citation.endpage | 3363 | - |
| dc.citation.number | 9 | - |
| dc.citation.startpage | 3359 | - |
| dc.citation.volume | 23 | - |
| dc.description.isOpenAccess | N | - |
| dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
| dc.contributor.affiliatedAuthor | Shin, Jongheon | - |
| dc.contributor.affiliatedAuthor | Yoon, Yeo Joon | - |
| dc.contributor.affiliatedAuthor | Oh, Dong-Chan | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | BIOSYNTHETIC GENE-CLUSTER | - |
| dc.subject.keywordPlus | ABSOLUTE-CONFIGURATION | - |
| dc.subject.keywordPlus | POLYKETIDE | - |
| dc.subject.keywordPlus | SEQUENCE | - |
| dc.subject.keywordPlus | NMR | - |
| dc.subject.keywordPlus | HITACHIMYCIN | - |
| dc.subject.keywordPlus | MECHANISM | - |
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