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Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.
Cited 18 time in
Web of Science
Cited 21 time in Scopus
- Authors
- Issue Date
- 2021-05
- Publisher
- American Chemical Society
- Citation
- Organic Letters, Vol.23 No.9, pp.3359-3363
- Abstract
- Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M).
- ISSN
- 1523-7060
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