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One-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene
Cited 13 time in
Web of Science
Cited 12 time in Scopus
- Authors
- Issue Date
- 2020-11-06
- Publisher
- American Chemical Society
- Citation
- Organic Letters, Vol.22 No.21, pp.8382-8386
- Abstract
- Herein, we describe the iron(III)-catalyzed oxidative coupling of alcohol/methyl arene with 2-amino phenyl ketone to synthesize 4-quinolone. Alcohols and methyl arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-butyl peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.
- ISSN
- 1523-7060
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