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Synthesis of 2-aryl quinazolinonesviairon-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds
Cited 37 time in
Web of Science
Cited 37 time in Scopus
- Authors
- Issue Date
- 2020-07
- Publisher
- Royal Society of Chemistry
- Citation
- Organic and Biomolecular Chemistry, Vol.18 No.28, pp.5435-5441
- Abstract
- Herein, we describe the direct synthesis of quinazolinonesviacross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp(3)carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95%. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles.
- ISSN
- 1477-0520
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