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Donghaecyclinones A-C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine Streptomyces sp.

Cited 14 time in Web of Science Cited 16 time in Scopus
Authors

Bae, Munhyung; An, Joon Soo; Hong, Seong-Heon; Bae, Eun Seo; Chung, Beomkoo; Kwon, Yun; Hong, Suckchang; Oh, Ki-Bong; Shin, Jongheon; Lee, Sang Kook; Oh, Dong-Chan

Issue Date
2020-02
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Citation
Marine Drugs, Vol.18 No.2, p. 121
Abstract
Chemical profiling of the Streptomyces sp. strain SUD119, which was isolated from a marine sediment sample collected from a volcanic island in Korea, led to the discovery of three new metabolites: donghaecyclinones A-C (1-3). The structures of 1-3 were found to be rearranged, multicyclic, angucyclinone-class compounds according to nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. The configurations of their stereogenic centers were successfully assigned using a combination of quantum mechanics-based computational methods for calculating the NMR shielding tensor (DP4 and CP3) as well as electronic circular dichroism (ECD) along with a modified version of Mosher's method. Donghaecyclinones A-C (1-3) displayed cytotoxicity against diverse human cancer cell lines (IC50: 6.7-9.6 mu M for 3).
ISSN
1660-3397
URI
https://hdl.handle.net/10371/202009
DOI
https://doi.org/10.3390/md18020121
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Development of methodologies using metal catalyst, Total synthesis of natural products

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