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Enantioselective synthesis of chiral α-thio-quaternary stereogenic centers via phase-transfer-catalyzed α-alkylation of α-acylthiomalonates : Enantioselective synthesis of chiral alpha-thio-quaternary stereogenic centers via phase-transfer-catalyzed alpha-alkylation of alpha-acylthiomalonates
DC Field | Value | Language |
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dc.contributor.author | Ha, Min Woo | - |
dc.contributor.author | Lee, Jun Young | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Lee, Geumwoo | - |
dc.contributor.author | Lee, Jae Kyun | - |
dc.contributor.author | Hong, Suckchang | - |
dc.contributor.author | Park, Hyeung-geun | - |
dc.date.accessioned | 2024-05-14T07:17:34Z | - |
dc.date.available | 2024-05-14T07:17:34Z | - |
dc.date.created | 2018-12-14 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | Journal of Organic Chemistry, Vol.83 No.2, pp.1011-1018 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202012 | - |
dc.description.abstract | An efficient synthetic method for establishing chiral α-thio-α-quaternary stereogenic center was successfully developed. The enantioselective α-alkylation of α-acylthiomalonates under phase-transfer catalytic conditions [50% aq. KOH, toluene, −20 °C, and (S,S)-3,4,5-trifluorophenyl-NAS bromide] provided the corresponding α-acylthio-α-alkylmalonates in high chemical yields (up to 99%) and high optical yields (up to 98% ee). | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Enantioselective synthesis of chiral α-thio-quaternary stereogenic centers via phase-transfer-catalyzed α-alkylation of α-acylthiomalonates | - |
dc.title.alternative | Enantioselective synthesis of chiral alpha-thio-quaternary stereogenic centers via phase-transfer-catalyzed alpha-alkylation of alpha-acylthiomalonates | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.joc.7b02605 | - |
dc.citation.journaltitle | Journal of Organic Chemistry | - |
dc.identifier.wosid | 000423252300045 | - |
dc.identifier.scopusid | 2-s2.0-85040807884 | - |
dc.citation.endpage | 1018 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 1011 | - |
dc.citation.volume | 83 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
dc.contributor.affiliatedAuthor | Park, Hyeung-geun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PRACTICAL ASYMMETRIC-SYNTHESIS | - |
dc.subject.keywordPlus | AMINO | - |
dc.subject.keywordPlus | SULFENYLATION | - |
dc.subject.keywordPlus | CONSTRUCTION | - |
dc.subject.keywordPlus | ARYLATION | - |
dc.subject.keywordPlus | ACIDS | - |
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