Publications
Detailed Information
Enantioselective synthesis of chiral α-thio-quaternary stereogenic centers via phase-transfer-catalyzed α-alkylation of α-acylthiomalonates : Enantioselective synthesis of chiral alpha-thio-quaternary stereogenic centers via phase-transfer-catalyzed alpha-alkylation of alpha-acylthiomalonates
Cited 4 time in
Web of Science
Cited 6 time in Scopus
- Authors
- Issue Date
- 2018-01
- Publisher
- American Chemical Society
- Citation
- Journal of Organic Chemistry, Vol.83 No.2, pp.1011-1018
- Abstract
- An efficient synthetic method for establishing chiral α-thio-α-quaternary stereogenic center was successfully developed. The enantioselective α-alkylation of α-acylthiomalonates under phase-transfer catalytic conditions [50% aq. KOH, toluene, −20 °C, and (S,S)-3,4,5-trifluorophenyl-NAS bromide] provided the corresponding α-acylthio-α-alkylmalonates in high chemical yields (up to 99%) and high optical yields (up to 98% ee).
- ISSN
- 0022-3263
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.