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Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents : Asymmetric synthesis and evaluation of alpha-quaternary chiral lactam derivatives as novel anticancer agents
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Cited 3 time in Scopus
- Authors
- Issue Date
- 2014-10
- Publisher
- 대한약학회
- Citation
- Archives of Pharmacal Research, Vol.37 No.10, pp.1264-1270
- Abstract
- Asymmetric synthesis of alpha-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums are reported. Among the developed lactam derivatives, the most active new compounds (S)-4m and (S)-4n synthesized via asymmetric phase-transfer catalytic alkylation in very high optical yields (98 % ee) show promising in vitro anticancer activities with low micromolar IC50 values against colon, uterus, lung, and breast human cancer cells.
- ISSN
- 0253-6269
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