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N-methylthioureas as new agonists of retinoic acid receptor-related orphan receptor
Cited 8 time in
Web of Science
Cited 8 time in Scopus
- Authors
- Issue Date
- 2012-08
- Publisher
- 대한약학회
- Citation
- Archives of Pharmacal Research, Vol.35 No.8, pp.1393-1401
- Abstract
- Thirty two thiourea derivatives were prepared and their agonistic activities on the retinoic acid receptor-related orphan receptor alpha (ROR alpha) were evaluated. The replacement of the 3-allyl-2-imino-thiazolidin-4-one moiety of the lead compound CGP52608 (1) with various functional group substituted aromatic rings, improved the agonistic activity of ROR alpha. Among the prepared derivatives, 1-methyl-3-(4-phenoxy-benzyl)-thiourea (32) showed 2.6-fold higher agonistic activity than CGP52608 in the ROR alpha-activation assay.
- ISSN
- 0253-6269
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