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Hetero-Integration of Silicon Nanomembranes with 2D Materials for Bioresorbable, Wireless Neurochemical System

Cited 30 time in Web of Science Cited 33 time in Scopus
Authors

Yang, Seung Min; Shim, Jae Hyung; Cho, Hyun-U; Jang, Tae-Min; Ko, Gwan-Jin; Shim, Jeongeun; Kim, Tae Hee; Zhu, Jia; Park, Sangun; Kim, Yoon Seok; Joung, Su-Yeon; Choe, Jong Chan; Shin, Jeong-Woong; Lee, Joong Hoon; Kang, Yu Min; Cheng, Huanyu; Jung, Youngmee; Lee, Chul-Ho; Jang, Dong Pyo; Hwang, Suk-Won

Issue Date
2022-04
Publisher
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Citation
Advanced Materials, Vol.34 No.14, p. 2108203
Abstract
Although neurotransmitters are key substances closely related to evaluating degenerative brain diseases as well as regulating essential functions in the body, many research efforts have not been focused on direct observation of such biochemical messengers, rather on monitoring relatively associated physical, mechanical, and electrophysiological parameters. Here, a bioresorbable silicon-based neurochemical analyzer incorporated with 2D transition metal dichalcogenides is introduced as a completely implantable brain-integrated system that can wirelessly monitor time-dynamic behaviors of dopamine and relevant parameters in a simultaneous mode. An extensive range of examinations of molybdenum/tungsten disulfide (MoS2/WS2) nanosheets and catalytic iron nanoparticles (Fe NPs) highlights the underlying mechanisms of strong chemical and target-specific responses to the neurotransmitters, along with theoretical modeling tools. Systematic characterizations demonstrate reversible, stable, and long-term operational performances of the degradable bioelectronics with excellent sensitivity and selectivity over those of non-dissolvable counterparts. A complete set of in vivo experiments with comparative analysis using carbon-fiber electrodes illustrates the capability for potential use as a clinically accessible tool to associated neurodegenerative diseases.
ISSN
0935-9648
URI
https://hdl.handle.net/10371/202227
DOI
https://doi.org/10.1002/adma.202108203
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  • College of Engineering
  • Department of Electrical and Computer Engineering
Research Area 2차원 반도체 소자 및 재료, High-Performance 2D Electronics, Low-Power 2D Electronics, 뉴로모픽 소자 및 응용기술, 저전력 소자 및 소자물리

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