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Fast and accurate protein structure search with Foldseek
Cited 150 time in
Web of Science
Cited 140 time in Scopus
- Authors
- Issue Date
- 2024-02
- Publisher
- Nature Publishing Group
- Citation
- Nature Biotechnology, Vol.42 No.2, pp.243-246
- Abstract
- As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a structural alphabet. Foldseek decreases computation times by four to five orders of magnitude with 86%, 88% and 133% of the sensitivities of Dali, TM-align and CE, respectively. Foldseek speeds up protein structural search by four to five orders of magnitude.
- ISSN
- 1087-0156
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