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Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer

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dc.contributor.authorShin, Hyun Mu-
dc.contributor.authorKim, Gwanghun-
dc.contributor.authorKim, Sangjib-
dc.contributor.authorSim, Ji Hyun-
dc.contributor.authorChoi, Jiyeob-
dc.contributor.authorKim, Minji-
dc.contributor.authorKwon, Minsuk-
dc.contributor.authorYe, Sang-Kyu-
dc.contributor.authorLee, Dong-Sup-
dc.contributor.authorCho, Seung Woo-
dc.contributor.authorKim, Seung Tae-
dc.contributor.authorLee, Jeeyun-
dc.contributor.authorKim, Hang-Rae-
dc.date.accessioned2024-05-16T01:27:40Z-
dc.date.available2024-05-16T01:27:40Z-
dc.date.created2021-05-24-
dc.date.created2021-05-24-
dc.date.created2021-05-24-
dc.date.created2021-05-24-
dc.date.created2021-05-24-
dc.date.issued2021-02-
dc.identifier.citationNature Communications, Vol.12 No.1, p. 975-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://hdl.handle.net/10371/202548-
dc.description.abstractAlthough tumor genomic profiling has identified small subsets of gastric cancer (GC) patients with clinical benefit from anti-PD-1 treatment, not all responses can be explained by tumor sequencing alone. We investigate epigenetic elements responsible for the differential response to anti-PD-1 therapy by quantitatively assessing the genome-wide chromatin accessibility of circulating CD8(+) T cells in patients' peripheral blood. Using an assay for transposase-accessible chromatin using sequencing (ATAC-seq), we identify unique open regions of chromatin that significantly distinguish anti-PD-1 therapy responders from non-responders. GC patients with high chromatin openness of circulating CD8(+) T cells are significantly enriched in the responder group. Concordantly, patients with high chromatin openness at specific genomic positions of their circulating CD8(+) T cells demonstrate significantly better survival than those with closed chromatin. Here we reveal that epigenetic characteristics of baseline CD8(+) T cells can be used to identify metastatic GC patients who may benefit from anti-PD-1 therapy. Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8(+) T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleChromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-021-21299-w-
dc.citation.journaltitleNature Communications-
dc.identifier.wosid000620683400003-
dc.identifier.scopusid2-s2.0-85100853990-
dc.citation.number1-
dc.citation.startpage975-
dc.citation.volume12-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorChoi, Jiyeob-
dc.contributor.affiliatedAuthorYe, Sang-Kyu-
dc.contributor.affiliatedAuthorLee, Dong-Sup-
dc.contributor.affiliatedAuthorKim, Hang-Rae-
dc.type.docTypeArticle-
dc.description.journalClass1-
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  • College of Medicine
Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism

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