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Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kim, Gwanghun | - |
dc.contributor.author | Kim, Sangjib | - |
dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Choi, Jiyeob | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Kwon, Minsuk | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Cho, Seung Woo | - |
dc.contributor.author | Kim, Seung Tae | - |
dc.contributor.author | Lee, Jeeyun | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.date.accessioned | 2024-05-16T01:27:40Z | - |
dc.date.available | 2024-05-16T01:27:40Z | - |
dc.date.created | 2021-05-24 | - |
dc.date.created | 2021-05-24 | - |
dc.date.created | 2021-05-24 | - |
dc.date.created | 2021-05-24 | - |
dc.date.created | 2021-05-24 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | Nature Communications, Vol.12 No.1, p. 975 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202548 | - |
dc.description.abstract | Although tumor genomic profiling has identified small subsets of gastric cancer (GC) patients with clinical benefit from anti-PD-1 treatment, not all responses can be explained by tumor sequencing alone. We investigate epigenetic elements responsible for the differential response to anti-PD-1 therapy by quantitatively assessing the genome-wide chromatin accessibility of circulating CD8(+) T cells in patients' peripheral blood. Using an assay for transposase-accessible chromatin using sequencing (ATAC-seq), we identify unique open regions of chromatin that significantly distinguish anti-PD-1 therapy responders from non-responders. GC patients with high chromatin openness of circulating CD8(+) T cells are significantly enriched in the responder group. Concordantly, patients with high chromatin openness at specific genomic positions of their circulating CD8(+) T cells demonstrate significantly better survival than those with closed chromatin. Here we reveal that epigenetic characteristics of baseline CD8(+) T cells can be used to identify metastatic GC patients who may benefit from anti-PD-1 therapy. Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8(+) T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-021-21299-w | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000620683400003 | - |
dc.identifier.scopusid | 2-s2.0-85100853990 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 975 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Choi, Jiyeob | - |
dc.contributor.affiliatedAuthor | Ye, Sang-Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Sup | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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