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IL-7Rαlow CD8+ T Cells from Healthy Individuals Are Anergic with Defective Glycolysis : IL-7R alpha(low) CD8(+) T Cells from Healthy Individuals Are Anergic with Defective Glycolysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Kim, Jin-Hee | - |
dc.contributor.author | Park, Ae Kyung | - |
dc.contributor.author | Lee, Jeeyun | - |
dc.contributor.author | Kim, Kyoung-Mee | - |
dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Choi, Kyungho | - |
dc.contributor.author | Choi, Eun Young | - |
dc.contributor.author | Kang, Insoo | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.date.accessioned | 2024-05-16T01:28:22Z | - |
dc.date.available | 2024-05-16T01:28:22Z | - |
dc.date.created | 2021-01-26 | - |
dc.date.created | 2021-01-26 | - |
dc.date.created | 2021-01-26 | - |
dc.date.created | 2021-01-26 | - |
dc.date.issued | 2020-12-01 | - |
dc.identifier.citation | Journal of Immunology, Vol.205 No.11, pp.2968-2978 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202564 | - |
dc.description.abstract | Effector memory (EM) CD8(+) T cells expressing lower levels of IL-7R alpha (IL-7R alpha(low)) from healthy individuals are partly compromised in vitro, but the identity of these cells has remained unclear. In this study, we demonstrate that human IL-7R alpha(lo)(w) EM CD8(+) T cells are naturally occurring anergic cells in vivo and impaired in proliferation and IL-2 production but competent in IFN-gamma and TNF-alpha production, a state that can be restored by IL-2 stimulation. IL-7R alpha(lo)(w) EM CD8(+) T cells show decreased expression of GATA3 and c-MYC and are defective in metabolic reprogramming toward glycolysis, a process required for the proliferation of T cells. However, IL-7R alpha(lo)(w) EM CD8(+) T cells can proliferate with TCR stimulation in the presence of IL-2 and IL-15, suggesting that these cells can be restored to normality or increased activity by inflammatory conditions and may serve as a reservoir for functional immunity. | - |
dc.language | 영어 | - |
dc.publisher | American Association of Immunologists | - |
dc.title | IL-7Rαlow CD8+ T Cells from Healthy Individuals Are Anergic with Defective Glycolysis | - |
dc.title.alternative | IL-7R alpha(low) CD8(+) T Cells from Healthy Individuals Are Anergic with Defective Glycolysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.1901470 | - |
dc.citation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | 000593103400004 | - |
dc.identifier.scopusid | 2-s2.0-85096815562 | - |
dc.citation.endpage | 2978 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 2968 | - |
dc.citation.volume | 205 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Shin, Hyun Mu | - |
dc.contributor.affiliatedAuthor | Choi, Kyungho | - |
dc.contributor.affiliatedAuthor | Choi, Eun Young | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Sup | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | HIV | - |
dc.subject.keywordPlus | EXHAUSTION | - |
dc.subject.keywordPlus | CAPACITY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CD127 | - |
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