Detailed Information

Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer

Cited 37 time in Web of Science Cited 37 time in Scopus

Youn, Je-In; Park, Su-Myeong; Park, Seyeon; Kim, Gamin; Lee, Hee-Jae; Son, Jimin; Hong, Min Hee; Ghaderpour, Aziz; Baik, Bumseo; Islam, Jahirul; Choi, Ji-Woong; Lee, Eun-Young; Kim, Hang-Rae; Seo, Sang-Uk; Paik, Soonmyung; Yoon, Hong In; Jung, Inkyung; Xin, Chun-Feng; Jin, Hyun-Tak; Cho, Byoung Chul; Seong, Seung-Yong; Ha, Sang-Jun; Kim, Hye Ryun

Issue Date
Nature Publishing Group
Scientific Reports, Vol.10 No.1, p. 9050
Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we sought to identify a more accurate predictive blood biomarker for evaluating anti-PD-1 response. We evaluated the frequencies of T cells, B cells, natural killer (NK) cells, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), mononuclear myeloid-derived suppressor cells (M-MDSCs), and Lox-1(+) PMN-MDSCs in peripheral blood samples of 62 NSCLC patients before and after nivolumab treatment. Correlation of immune-cell population frequencies with treatment response, progression-free survival, and overall survival was also determined. After the first treatment, the median NK cell percentage was significantly higher in responders than in non-responders, while the median Lox-1+ PMN-MDSC percentage showed the opposite trend. NK cell frequencies significantly increased in responders but not in non-responders. NK cell frequency inversely correlated with that of Lox-1(+) PMN-MDSCs after the first treatment cycle. The NK cell-to-Lox-1(+) PMN-MDSC ratio (NMR) was significantly higher in responders than in non-responders. Patients with NMRs >= 5.75 after the first cycle had significantly higher objective response rates and longer progression-free and overall survival than those with NMRs <5.75. NMR shows promise as an early predictor of response to further anti-PD-1 therapy.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Medicine
Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.