Publications

Detailed Information

Taurodeoxycholate increases the number of myeloid-derived suppressor cells that ameliorate sepsis in mice

Cited 32 time in Web of Science Cited 34 time in Scopus
Authors

Chang, Sooghee; Kim, Youn-Hee; Kim, Young-Joo; Kim, Young-Woo; Moon, Sungyoon; Lee, Yong Yook; Jung, Jin Sun; Kim, Youngsoo; Jung, Hi-Eun; Kim, Tae-Joo; Cheong, Taek-Chin; Moon, Hye-Jung; Cho, Jung-Ah; Kim, Hang-Rae; Han, Dohyun; Na, Yirang; Seok, Seung-Hyeok; Cho, Nam-Hyuk; Lee, Hai-Chon; Nam, Eun-Hee; Cho, Hyosuk; Choi, Murim; Minato, Nagahiro; Seong, Seung-Yong

Issue Date
2018-09
Publisher
Frontiers Media S.A.
Citation
Frontiers in Immunology, Vol.9 No.SEP, p. 1984
Abstract
Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during sepsis. TDCA increases the number of granulocytic myeloid-derived suppressor cells (MDSCLT) distinctive from MDSCs obtained without TDCA treatment (MDSCL) in the spleen of septic mice. FACS-sorted MDSCLT cells suppress T-cell proliferation and confer protection against sepsis when adoptively transferred better than MDSCL. Proteogenomic analysis indicated that TDCA controls chromatin silencing, alternative splicing, and translation of the immune proteome of MDSCLT, which increases the expression of anti-inflammatory molecules such as oncostatin, lactoferrin and CD244. TDCA also decreases the expression of pro-inflammatory molecules such as neutrophil elastase. These findings suggest that TDCA globally edits the proteome to increase the number of MDSCLT cells and affect their immune-regulatory functions to resolve systemic inflammation during sepsis.
ISSN
1664-3224
URI
https://hdl.handle.net/10371/202574
DOI
https://doi.org/10.3389/fimmu.2018.01984
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Medicine
Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share