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T cell-specific knockout of STAT3 ameliorates dextran sulfate sodium-induced colitis by reducing the inflammatory response
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Sun-Ho | - |
dc.contributor.author | Seo, Eun-Bi | - |
dc.contributor.author | Lee, Song-Hee | - |
dc.contributor.author | Cho, Chung-Hyun | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.date.accessioned | 2024-05-16T01:29:02Z | - |
dc.date.available | 2024-05-16T01:29:02Z | - |
dc.date.created | 2019-07-17 | - |
dc.date.created | 2019-07-17 | - |
dc.date.created | 2019-07-17 | - |
dc.date.created | 2019-07-17 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | Immune Network, Vol.18 No.4, p. e30 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202575 | - |
dc.description.abstract | Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD). Our previous study demonstrated that STAT3 activation by IL-6 in colonic epithelial cells exacerbates experimental ulcerative colitis. Activated T lymphocytes are also found in ulcerative colitis patients with intestinal inflammation, but the role of STAT3 in T cells remains elusive. To determine the STAT3 function of T cells in intestinal inflammation, we generated T cell-specific STAT3 knockout (KO) mice and used dextran sulfate sodium (DSS) to induce colitis. In this study, we demonstrated that T cell-specific STAT3 deletion alleviated DSS-induced colitis in mice, resulting in reduced histological scores and myeloperoxidase (MPO) activity. Importantly, the population of T cells in the spleen and lymph nodes was significantly decreased in the control and DSS-induced groups of STAT3 KO mice. In addition, STAT3 deficiency in T cells markedly reduced the production of interferon (IFN)-gamma, IL-6, and IL-17A, whereas IL-10 secretion was increased. Collectively, the results suggest that STAT3 in T cells may be a therapeutic target in ulcerative colitis by balancing the immune response through T cell homeostasis. | - |
dc.language | 영어 | - |
dc.publisher | 대한면역학회 | - |
dc.title | T cell-specific knockout of STAT3 ameliorates dextran sulfate sodium-induced colitis by reducing the inflammatory response | - |
dc.type | Article | - |
dc.identifier.doi | 10.4110/in.2018.18.e30 | - |
dc.citation.journaltitle | Immune Network | - |
dc.identifier.wosid | 000443358400006 | - |
dc.identifier.scopusid | 2-s2.0-85052905432 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | e30 | - |
dc.citation.volume | 18 | - |
dc.identifier.kciid | ART002381067 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Chung-Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Sung Joon | - |
dc.contributor.affiliatedAuthor | Kim, Sang Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.contributor.affiliatedAuthor | Ye, Sang-Kyu | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BOWEL-DISEASE | - |
dc.subject.keywordPlus | IL-6 | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordAuthor | T lymphocytes | - |
dc.subject.keywordAuthor | STAT3 transcription factor | - |
dc.subject.keywordAuthor | DSS-induced colitis | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Homeostasis | - |
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