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Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin-Hee | - |
dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Lee, Sunkyung | - |
dc.contributor.author | Seol, Min A. | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Lee, Yun Jong | - |
dc.contributor.author | Choi, Yun Jung | - |
dc.contributor.author | Yoo, Wan-Hee | - |
dc.contributor.author | Kim, Jin Hyun | - |
dc.contributor.author | Kim, Wan-Uk | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Kim, Jin-Hong | - |
dc.contributor.author | Kang, Insoo | - |
dc.contributor.author | Kang, Seong Wook | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.date.accessioned | 2024-05-16T01:29:26Z | - |
dc.date.available | 2024-05-16T01:29:26Z | - |
dc.date.created | 2018-09-14 | - |
dc.date.created | 2018-09-14 | - |
dc.date.created | 2018-09-14 | - |
dc.date.created | 2018-09-14 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | Frontiers in Immunology, Vol.8, p. 1376 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202582 | - |
dc.description.abstract | Interleukin-7 (IL-7), which is required for the development and survival of T cells in the thymus and periphery, plays a role in joint destruction. However, it remains unclear how IL-7 affects osteoclast formation. Thus, we investigated the mechanism by which IL-7 induced osteoclast formation through IL-7 receptor a (IL-7R alpha) in osteoclast precursors. We cultured peripheral blood mononuclear cells or synovial fluid mononuclear cells with IL-7 in the presence or absence of an appropriate inhibitor to analyze osteoclast formation. We also constructed IL-7R alpha-expressing RAW264.7 cells to uncover the mechanism(s) by which IL-7 induced osteoclast formation differed from that of receptor activator of nuclear factor.B ligand (RANKL). We found that IL-7 induced osteoclast formation of human monocytes from peripheral blood or synovial fluid in a RANKL-independent and a signal transducer and activator of transcription 5 (STAT5)-dependent manner. IL-7-induced osteoclasts had unique characteristics, such as small, multinucleated tartrate-resistant acid phosphatase positive cells and no alterations even when RANKL was added after IL-7 pretreatment. RAW264.7 cells, if overexpressing IL-7Ra, also were able to differentiate into osteoclasts by IL-7 through a STAT5 signaling pathway. Furthermore, IL-7-induced osteoclast formation was repressed by inhibitors of the IL-7R signaling molecules Janus kinase and STAT5. Our findings demonstrate that IL-7 is a truly osteoclastogenic factor, which may induce osteoclast formation via activation of STAT5, independent of RANKL. We also suggest the possibility that an IL-7R pathway blocker could alleviate joint damage by inhibiting osteoclast formation, especially in inflammatory conditions. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fimmu.2017.01376 | - |
dc.citation.journaltitle | Frontiers in Immunology | - |
dc.identifier.wosid | 000413288900001 | - |
dc.identifier.scopusid | 2-s2.0-85031723866 | - |
dc.citation.startpage | 1376 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Ye, Sang-Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Eun Bong | - |
dc.contributor.affiliatedAuthor | Lee, Yun Jong | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Sup | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Hong | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | SYNOVIAL FIBROBLASTS | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | OSTEOPROTEGERIN LIGAND | - |
dc.subject.keywordPlus | INFLAMMATORY ARTHRITIS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | BONE-RESORPTION | - |
dc.subject.keywordPlus | CD4+T CELLS | - |
dc.subject.keywordPlus | RANKL | - |
dc.subject.keywordAuthor | osteoclast | - |
dc.subject.keywordAuthor | intereleukin-7 | - |
dc.subject.keywordAuthor | IL-7 receptor alpha | - |
dc.subject.keywordAuthor | STAT5 | - |
dc.subject.keywordAuthor | RANKL | - |
dc.subject.keywordAuthor | monocyte | - |
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