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Transient expression of ZBTB32 in anti-viral CD8(+) T cells limits the magnitude of the effector response and the generation of memory
DC Field | Value | Language |
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dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kapoor, Varun N. | - |
dc.contributor.author | Kim, Gwanghun | - |
dc.contributor.author | Li, Peng | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Suresh, M. | - |
dc.contributor.author | Kaech, Susan M. | - |
dc.contributor.author | Wherry, E. John | - |
dc.contributor.author | Selin, Liisa K. | - |
dc.contributor.author | Leonard, Warren J. | - |
dc.contributor.author | Welsh, Raymond M. | - |
dc.contributor.author | Berg, Leslie J. | - |
dc.date.accessioned | 2024-05-16T01:30:44Z | - |
dc.date.available | 2024-05-16T01:30:44Z | - |
dc.date.created | 2018-08-30 | - |
dc.date.created | 2018-08-30 | - |
dc.date.created | 2018-08-30 | - |
dc.date.created | 2018-08-30 | - |
dc.date.created | 2018-08-30 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | PLoS Pathogens, Vol.13 No.8, p. e1006544 | - |
dc.identifier.issn | 1553-7366 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202601 | - |
dc.description.abstract | Virus infections induce CD8(+) T cell responses comprised of a large population of terminal effector cells and a smaller subset of long-lived memory cells. The transcription factors regulating the relative expansion versus the long-term survival potential of anti-viral CD8(+) T cells are not completely understood. We identified ZBTB32 as a transcription factor that is transiently expressed in effector CD8(+) T cells. After acute virus infection, CD8(+) T cells deficient in ZBTB32 showed enhanced virus-specific CD8(+) T cell responses, and generated increased numbers of virus-specific memory cells; in contrast, persistent expression of ZBTB32 suppressed memory cell formation. The dysregulation of CD8(+) T cell responses in the absence of ZBTB32 was catastrophic, as Zbtb32(-/-) mice succumbed to a systemic viral infection and showed evidence of severe lung pathology. We found that ZBTB32 and Blimp-1 were co-expressed following CD8(+) T cell activation, bound to each other, and cooperatively regulated Blimp-1 target genes Eomes and Cd27. These findings demonstrate that ZBTB32 is a key transcription factor in CD8(+) effector T cells that is required for the balanced regulation of effector versus memory responses to infection. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | Transient expression of ZBTB32 in anti-viral CD8(+) T cells limits the magnitude of the effector response and the generation of memory | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.ppat.1006544 | - |
dc.citation.journaltitle | PLoS Pathogens | - |
dc.identifier.wosid | 000408758400023 | - |
dc.identifier.scopusid | 2-s2.0-85028637187 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | e1006544 | - |
dc.citation.volume | 13 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | - |
dc.subject.keywordPlus | INHIBITORY RECEPTOR PD-1 | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | CLONAL EXPANSION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | REPRESSOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | BLIMP-1 | - |
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