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Transient expression of ZBTB32 in anti-viral CD8(+) T cells limits the magnitude of the effector response and the generation of memory

DC Field Value Language
dc.contributor.authorShin, Hyun Mu-
dc.contributor.authorKapoor, Varun N.-
dc.contributor.authorKim, Gwanghun-
dc.contributor.authorLi, Peng-
dc.contributor.authorKim, Hang-Rae-
dc.contributor.authorSuresh, M.-
dc.contributor.authorKaech, Susan M.-
dc.contributor.authorWherry, E. John-
dc.contributor.authorSelin, Liisa K.-
dc.contributor.authorLeonard, Warren J.-
dc.contributor.authorWelsh, Raymond M.-
dc.contributor.authorBerg, Leslie J.-
dc.date.accessioned2024-05-16T01:30:44Z-
dc.date.available2024-05-16T01:30:44Z-
dc.date.created2018-08-30-
dc.date.created2018-08-30-
dc.date.created2018-08-30-
dc.date.created2018-08-30-
dc.date.created2018-08-30-
dc.date.issued2017-08-
dc.identifier.citationPLoS Pathogens, Vol.13 No.8, p. e1006544-
dc.identifier.issn1553-7366-
dc.identifier.urihttps://hdl.handle.net/10371/202601-
dc.description.abstractVirus infections induce CD8(+) T cell responses comprised of a large population of terminal effector cells and a smaller subset of long-lived memory cells. The transcription factors regulating the relative expansion versus the long-term survival potential of anti-viral CD8(+) T cells are not completely understood. We identified ZBTB32 as a transcription factor that is transiently expressed in effector CD8(+) T cells. After acute virus infection, CD8(+) T cells deficient in ZBTB32 showed enhanced virus-specific CD8(+) T cell responses, and generated increased numbers of virus-specific memory cells; in contrast, persistent expression of ZBTB32 suppressed memory cell formation. The dysregulation of CD8(+) T cell responses in the absence of ZBTB32 was catastrophic, as Zbtb32(-/-) mice succumbed to a systemic viral infection and showed evidence of severe lung pathology. We found that ZBTB32 and Blimp-1 were co-expressed following CD8(+) T cell activation, bound to each other, and cooperatively regulated Blimp-1 target genes Eomes and Cd27. These findings demonstrate that ZBTB32 is a key transcription factor in CD8(+) effector T cells that is required for the balanced regulation of effector versus memory responses to infection.-
dc.language영어-
dc.publisherPublic Library of Science-
dc.titleTransient expression of ZBTB32 in anti-viral CD8(+) T cells limits the magnitude of the effector response and the generation of memory-
dc.typeArticle-
dc.identifier.doi10.1371/journal.ppat.1006544-
dc.citation.journaltitlePLoS Pathogens-
dc.identifier.wosid000408758400023-
dc.identifier.scopusid2-s2.0-85028637187-
dc.citation.number8-
dc.citation.startpagee1006544-
dc.citation.volume13-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorKim, Hang-Rae-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusLYMPHOCYTIC CHORIOMENINGITIS VIRUS-
dc.subject.keywordPlusINHIBITORY RECEPTOR PD-1-
dc.subject.keywordPlusVIRAL-INFECTION-
dc.subject.keywordPlusCLONAL EXPANSION-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusREPRESSOR-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCYTOKINE-
dc.subject.keywordPlusBLIMP-1-
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  • College of Medicine
Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism

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