Publications
Detailed Information
Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Seon Young | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Ryu, Pan Dong | - |
dc.contributor.author | Lee, So Yeong | - |
dc.date.accessioned | 2024-05-16T01:31:00Z | - |
dc.date.available | 2024-05-16T01:31:00Z | - |
dc.date.created | 2018-08-08 | - |
dc.date.created | 2018-08-08 | - |
dc.date.created | 2018-08-08 | - |
dc.date.created | 2018-08-08 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | BMC pharmacology & toxicology, Vol.18, p. 14 | - |
dc.identifier.issn | 2050-6511 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202608 | - |
dc.description.abstract | Background: Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (Non-SP cells). Also, several ion channels are responsible for the drug resistance and proliferation of SP cells in cancer. Methods: To confirm the expression and function of voltage-gated potassium (Kv) channels of SP cells, these cells, as well as highly expressed ATP-binding cassette (ABC) transporters and stemness genes, were isolated from a gefitinib-resistant human lung adenocarcinoma cell line (NCI-H460), using Hoechst 33342 efflux. Results: In the present study, we found that mRNA expression of Kv channels in SP cells was different compared to Non-SP cells, and the resistance of SP cells to gefitinib was weakened with a combination treatment of gefitinib and Kv channel blockers or a Kv7 opener, compared to single-treatment gefitinib, through inhibition of the Ras-Raf signaling pathway. Conclusions: The findings indicate that Kv channels in SP cells could be new targets for reducing the resistance to gefitinib. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s40360-017-0118-9 | - |
dc.citation.journaltitle | BMC pharmacology & toxicology | - |
dc.identifier.wosid | 000397893700001 | - |
dc.identifier.scopusid | 2-s2.0-85013287859 | - |
dc.citation.startpage | 14 | - |
dc.citation.volume | 18 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.contributor.affiliatedAuthor | Ryu, Pan Dong | - |
dc.contributor.affiliatedAuthor | Lee, So Yeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TYROSINE KINASE INHIBITORS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | THERAPEUTIC IMPLICATIONS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | K+ CHANNEL | - |
dc.subject.keywordPlus | ABCG2 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GLIOMA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | Lung cancer cell | - |
dc.subject.keywordAuthor | Drug resistance | - |
dc.subject.keywordAuthor | Side population | - |
dc.subject.keywordAuthor | Voltage-gated potassium channel | - |
dc.subject.keywordAuthor | Combination therapy | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.