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CD4(+)FOXP3(+) Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome : CD4+FOXP3+ Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome

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dc.contributor.authorLee, Young Ah-
dc.contributor.authorKim, Hang-Rae-
dc.contributor.authorLee, Jeong Seon-
dc.contributor.authorJung, Hae Woon-
dc.contributor.authorKim, Hwa Young-
dc.contributor.authorLee, Gyung Min-
dc.contributor.authorLee, Jieun-
dc.contributor.authorSim, Ji Hyun-
dc.contributor.authorOh, Sae Jin-
dc.contributor.authorChung, Doo Hyun-
dc.contributor.authorShin, Choong Ho-
dc.contributor.authorYang, Sei Won-
dc.date.accessioned2024-05-16T01:31:27Z-
dc.date.available2024-05-16T01:31:27Z-
dc.date.created2018-09-20-
dc.date.created2018-09-20-
dc.date.created2018-09-20-
dc.date.issued2015-12-
dc.identifier.citationPLoS ONE, Vol.10 No.12, p. e0144549-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10371/202621-
dc.description.abstractObjective We investigated whether the frequency, phenotype, and suppressive function of CD4(+)FOXP3(+) regulatory T cells (Tregs) are altered in young TS patients with the 45, X karyotype compared to age-matched controls. Design and Methods Peripheral blood mononuclear cells from young TS patients (n = 24, 17.4-35.9 years) and healthy controls (n = 16) were stained with various Treg markers to characterize their phenotypes. Based on the presence of thyroid autoimmunity, patients were categorized into TS (-) (n = 7) and TS (+) (n = 17). Tregs sorted for CD4(+)CD25(bright) were co-cultured with autologous CD4(+)CD25(-) target cells in the presence of anti-CD3 and -CD28 antibodies to assess their suppressive function. Results Despite a lower frequency of CD4(+) T cells in the TS (-) and TS (+) patients (mean 30.8% and 31.7%, vs. 41.2%; P = 0.003 and P < 0.001, respectively), both groups exhibited a higher frequency of FOXP3(+) Tregs among CD4(+) T cells compared with controls (means 1.99% and 2.05%, vs. 1.33%; P = 0.029 and P = 0.004, respectively). There were no differences in the expression of CTLA-4 and the frequency of Tregs expressing CXCR3(+), and CCR4(+)CCR6(+) among the three groups. However, the ability of Tregs to suppress the in vitro proliferation of autologous CD4(+)CD25(-) T cells was significantly impaired in the TS (-) and TS (+) patients compared to controls (P = 0.003 and P = 0.041). Meanwhile, both the TS (-) and TS (+) groups had lower frequencies of naive cells (P = 0.001 for both) but higher frequencies of effector memory cells (P = 0.004 and P = 0.002) than did the healthy control group. Conclusions The Tregs of the TS patients could not efficiently suppress the proliferation of autologous effector T cells, despite their increased frequency in peripheral CD4(+) T cells.-
dc.language영어-
dc.publisherPublic Library of Science-
dc.titleCD4(+)FOXP3(+) Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome-
dc.title.alternativeCD4+FOXP3+ Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome-
dc.typeArticle-
dc.identifier.doi10.1371/journal.pone.0144549-
dc.citation.journaltitlePLoS ONE-
dc.identifier.wosid000367451400007-
dc.identifier.scopusid2-s2.0-84957593048-
dc.citation.number12-
dc.citation.startpagee0144549-
dc.citation.volume10-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorKim, Hang-Rae-
dc.contributor.affiliatedAuthorChung, Doo Hyun-
dc.contributor.affiliatedAuthorShin, Choong Ho-
dc.contributor.affiliatedAuthorYang, Sei Won-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusFOLLOW-UP-
dc.subject.keywordPlusWOMEN-
dc.subject.keywordPlusLYMPHOCYTES-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusFOXP3-
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Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism

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