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CD4(+)FOXP3(+) Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome : CD4+FOXP3+ Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ah | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Lee, Jeong Seon | - |
dc.contributor.author | Jung, Hae Woon | - |
dc.contributor.author | Kim, Hwa Young | - |
dc.contributor.author | Lee, Gyung Min | - |
dc.contributor.author | Lee, Jieun | - |
dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Oh, Sae Jin | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Shin, Choong Ho | - |
dc.contributor.author | Yang, Sei Won | - |
dc.date.accessioned | 2024-05-16T01:31:27Z | - |
dc.date.available | 2024-05-16T01:31:27Z | - |
dc.date.created | 2018-09-20 | - |
dc.date.created | 2018-09-20 | - |
dc.date.created | 2018-09-20 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | PLoS ONE, Vol.10 No.12, p. e0144549 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202621 | - |
dc.description.abstract | Objective We investigated whether the frequency, phenotype, and suppressive function of CD4(+)FOXP3(+) regulatory T cells (Tregs) are altered in young TS patients with the 45, X karyotype compared to age-matched controls. Design and Methods Peripheral blood mononuclear cells from young TS patients (n = 24, 17.4-35.9 years) and healthy controls (n = 16) were stained with various Treg markers to characterize their phenotypes. Based on the presence of thyroid autoimmunity, patients were categorized into TS (-) (n = 7) and TS (+) (n = 17). Tregs sorted for CD4(+)CD25(bright) were co-cultured with autologous CD4(+)CD25(-) target cells in the presence of anti-CD3 and -CD28 antibodies to assess their suppressive function. Results Despite a lower frequency of CD4(+) T cells in the TS (-) and TS (+) patients (mean 30.8% and 31.7%, vs. 41.2%; P = 0.003 and P < 0.001, respectively), both groups exhibited a higher frequency of FOXP3(+) Tregs among CD4(+) T cells compared with controls (means 1.99% and 2.05%, vs. 1.33%; P = 0.029 and P = 0.004, respectively). There were no differences in the expression of CTLA-4 and the frequency of Tregs expressing CXCR3(+), and CCR4(+)CCR6(+) among the three groups. However, the ability of Tregs to suppress the in vitro proliferation of autologous CD4(+)CD25(-) T cells was significantly impaired in the TS (-) and TS (+) patients compared to controls (P = 0.003 and P = 0.041). Meanwhile, both the TS (-) and TS (+) groups had lower frequencies of naive cells (P = 0.001 for both) but higher frequencies of effector memory cells (P = 0.004 and P = 0.002) than did the healthy control group. Conclusions The Tregs of the TS patients could not efficiently suppress the proliferation of autologous effector T cells, despite their increased frequency in peripheral CD4(+) T cells. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | CD4(+)FOXP3(+) Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome | - |
dc.title.alternative | CD4+FOXP3+ Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0144549 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000367451400007 | - |
dc.identifier.scopusid | 2-s2.0-84957593048 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | e0144549 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.contributor.affiliatedAuthor | Chung, Doo Hyun | - |
dc.contributor.affiliatedAuthor | Shin, Choong Ho | - |
dc.contributor.affiliatedAuthor | Yang, Sei Won | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | FOXP3 | - |
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