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Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Chang, Soog-Hee | - |
dc.contributor.author | Kim, In Je | - |
dc.contributor.author | Lipsky, Peter E. | - |
dc.contributor.author | Lee, Jisoo | - |
dc.date.accessioned | 2024-05-16T01:31:47Z | - |
dc.date.available | 2024-05-16T01:31:47Z | - |
dc.date.created | 2018-10-23 | - |
dc.date.created | 2018-10-23 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | Arthritis Research and Therapy, Vol.17, p. 190 | - |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202630 | - |
dc.description.abstract | Introduction: Pre-naive B cells represent an intermediate stage in human B-cell development with some functions of mature cells, but their involvement in immune responses is unknown. The aim of this study was to determine the functional role of normal pre-naive B cells during immune responses and possible abnormalities in systemic lupus erythematosus (SLE) that might contribute to disease pathogenesis. Methods: Pre-naive, naive, and memory B cells from healthy individuals and SLE patients were stimulated through CD40 and were analyzed for interleukin-10 (IL-10) production and co-stimulatory molecule expression and their regulation of T-cell activation. Autoreactivity of antibodies produced by pre-naive B cells was tested by measuring immunoglobulin M (IgM) autoantibodies in culture supernatants after differentiation. Results: CD40-stimulated pre-naive B cells produce larger amounts of IL-10 but did not suppress CD4(+) T-cell cytokine production. Activated pre-naive B cells demonstrated IL-10-mediated ineffective promotion of CD4(+) T-cell proliferation and induction of CD4(+)FoxP3(+) T cells and IL-10 independent impairment of co-stimulatory molecule expression and tumor necrosis factor-alpha (TNF-alpha) and IL-6 production. IgM antibodies produced by differentiated pre-naive B cells were reactive to single-stranded deoxyribonucleic acid. SLE pre-naive B cells were defective in producing IL-10, and co-stimulatory molecule expression was enhanced, resulting in promotion of robust CD4(+) T-cell proliferation. Conclusions: There is an inherent and IL-10-mediated mechanism that limits the capacity of normal pre-naive B cells from participating in cellular immune response, but these cells can differentiate into autoantibody-secreting plasma cells. In SLE, defects in IL-10 secretion permit pre-naive B cells to promote CD4(+) T-cell activation and may thereby enhance the development of autoimmunity. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13075-015-0687-1 | - |
dc.citation.journaltitle | Arthritis Research and Therapy | - |
dc.identifier.wosid | 000358400800002 | - |
dc.identifier.scopusid | 2-s2.0-84938291830 | - |
dc.citation.startpage | 190 | - |
dc.citation.volume | 17 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | B7-2 CD86 EXPRESSION | - |
dc.subject.keywordPlus | COSTIMULATORY MOLECULES | - |
dc.subject.keywordPlus | AUTOANTIBODY PRODUCTION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | B10 CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | RECEPTOR | - |
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