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The Lupus Susceptibility Locus Sle1 Facilitates the Peripheral Development and Selection of Anti-DNA B Cells through Impaired Receptor Editing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Soog-Hee | - |
dc.contributor.author | Kim, Tae-Joo | - |
dc.contributor.author | Kim, Young-Joo | - |
dc.contributor.author | Liu, Yang | - |
dc.contributor.author | Min, So-Youn | - |
dc.contributor.author | Park, Min-Jung | - |
dc.contributor.author | Park, Hyun-Sil | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.contributor.author | Nam, Ki-Hoan | - |
dc.contributor.author | Kim, Ho-Youn | - |
dc.contributor.author | Mohan, Chandra | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.date.accessioned | 2024-05-16T01:32:14Z | - |
dc.date.available | 2024-05-16T01:32:14Z | - |
dc.date.created | 2020-08-24 | - |
dc.date.created | 2020-08-24 | - |
dc.date.created | 2020-08-24 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | Journal of Immunology, Vol.192 No.12, pp.5579-5585 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202644 | - |
dc.description.abstract | Systemic lupus erythematosus is characterized by the spontaneous production of IgG autoantibodies in patients and lupus-prone mice. In this study, we investigated the effect of the Sle1 lupus susceptibility locus on the peripheral development of 56R(+) anti-DNA transgenic B cells by tracking 56R(+) B cells in mice without (B6.56R) or with (B6.Sle1.56R) the Sle1 locus. Compared with B6.56R mice, B6.Sle1.56R mice exhibited increased class-switched IgG2a anti-DNA Abs in their serum, encoded by the transgene. Interestingly, within the spleen, Sle1 facilitated the development of these cells into clusters of IgG2a class-switched B cells juxtaposed to CD4(+) T cells within extrafollicular sites. Through sequence analysis of B cell hybridomas, we also found that B cells from B6.Sle1.56R mice are inefficient at Ig H and L chain editing. Thus, the Ig H chains in Sle1.56R(+) B cells are partnered more often with cationic L chains that facilitate DNA binding. Taken together, these findings indicate that the Sle1 lupus-susceptibility locus may facilitate the emergence of anti-DNA B cells by subduing BCR revision and possibly by shaping the extrafollicular development of effector B cells, although the precise molecular mechanisms await further study. | - |
dc.language | 영어 | - |
dc.publisher | American Association of Immunologists | - |
dc.title | The Lupus Susceptibility Locus Sle1 Facilitates the Peripheral Development and Selection of Anti-DNA B Cells through Impaired Receptor Editing | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.1201558 | - |
dc.citation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | 000337172100017 | - |
dc.identifier.scopusid | 2-s2.0-84902134787 | - |
dc.citation.endpage | 5585 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 5579 | - |
dc.citation.volume | 192 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENETIC DISSECTION | - |
dc.subject.keywordPlus | PLASMA-CELL | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | ERYTHEMATOSUS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | REARRANGEMENT | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | HYPERMUTATION | - |
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