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Anti-Asthmatic Activities of an Ethanol Extract of Aster yomena in an Ovalbumin-Induced Murine Asthma Model

Cited 15 time in Web of Science Cited 17 time in Scopus
Authors

Sim, Ji Hyun; Lee, Hyun Seung; Lee, Sunkyung; Park, Dae Eun; Oh, Keunhee; Hwang, Kyung-A; Kang, Hye-Ryun; Ye, Sang-Kyu; Kim, Hang-Rae

Issue Date
2014-05
Publisher
한국식품영양과학회
Citation
Journal of Medicinal Food, Vol.17 No.5, pp.606-611
Abstract
Aster yomena is used in traditional remedies to treat cough, asthma and insect bites; however, its therapeutic mechanism is not completely understood. To elucidate the anti-asthmatic effect of A. yomena, we investigated the anti-asthmatic characteristics of an alcohol extract of A. yomena in an ovalbumin (OVA)-induced murine asthma model. In this study, we showed that A. yomena extract inhibited the overall pathophysiological features of asthma by suppressing Th2 responses and enzymes associated with the production of inflammatory mediators. This suppression resulted in decreased Th2 type cytokines and eosinophils in the bronchoalveolar lavage fluid and OVA-specific IgE in serum. Additionally, A. yomena extract significantly decreased airway hyperresponsiveness and abrogated the histopathological changes in the lungs, which reached normal levels in the OVA-challenged mice treated with A. yomena extract. These findings suggest that A. yomena could be a promising natural agent for treating bronchial asthma in humans.
ISSN
1096-620X
URI
https://hdl.handle.net/10371/202646
DOI
https://doi.org/10.1089/jmf.2013.2939
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Research Area Function, Immune modulation by metabolites, T-cell anergy, differentiation of memory CD8+ T cells, metabolism

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