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Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-alpha, and ROS production in Gulo (-/-)(Vit C-Insufficient) mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyemin | - |
dc.contributor.author | Bae, Seyeon | - |
dc.contributor.author | Kim, Yejin | - |
dc.contributor.author | Cho, Chung-Hyun | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Hwang, Young-il | - |
dc.contributor.author | Kang, Jae Seung | - |
dc.contributor.author | Lee, Wang Jae | - |
dc.date.accessioned | 2024-05-16T01:32:30Z | - |
dc.date.available | 2024-05-16T01:32:30Z | - |
dc.date.created | 2020-12-02 | - |
dc.date.created | 2020-12-02 | - |
dc.date.created | 2020-12-02 | - |
dc.date.created | 2020-12-02 | - |
dc.date.created | 2020-12-02 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Free Radical Biology and Medicine, Vol.65, pp.573-583 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202652 | - |
dc.description.abstract | It is thought that vitamin C has protective roles on stress-induced heart damage and the development of cardiovascular diseases, but its precise role and mechanisms are unclear. In the present study, we investigated the specific mechanisms by which vitamin C leads to protecting the heart from stress-induced damage in the Gulo(-/-) mice which cannot synthesize vitamin C like humans. By exposure to stress (1 h/day), the heartbeat and cardiac output in vitamin C-insufficient Gulo(-/-) mice were definitely decreased, despite a significant increase of adrenaline (ADR) and noradrenaline (NA) production. A change of cardiac structure caused by the death of cardiomyocytes and an increased expression of matrix metalloprotease (MMP)-2 and -9 were also found. Moreover, lipid peroxidation and the production of tumor necrosis factor-alpha (TNF-alpha) in the heart were increased. Finally, all vitamin C-insufficient Gulo(-/-) mice were expired within 2 weeks. Interestingly, all of the findings in vitamin C-insufficient Gulo(-/-) mice were completely prevented by the supplementation of a sufficient amount of vitamin C. Taken together, vitamin C insufficiency increases the risk of stress-induced cardiac damage with structural and functional changes arising from the apoptosis of cardiomyocytes. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-alpha, and ROS production in Gulo (-/-)(Vit C-Insufficient) mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2013.07.023 | - |
dc.citation.journaltitle | Free Radical Biology and Medicine | - |
dc.identifier.wosid | 000328868900055 | - |
dc.identifier.scopusid | 2-s2.0-84884528684 | - |
dc.citation.endpage | 583 | - |
dc.citation.startpage | 573 | - |
dc.citation.volume | 65 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Chung-Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Sung Joon | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Jin | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.contributor.affiliatedAuthor | Hwang, Young-il | - |
dc.contributor.affiliatedAuthor | Kang, Jae Seung | - |
dc.contributor.affiliatedAuthor | Lee, Wang Jae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | ASCORBIC-ACID | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Vitamin C insufficiency | - |
dc.subject.keywordAuthor | Gulo(-/-) mice | - |
dc.subject.keywordAuthor | Stress | - |
dc.subject.keywordAuthor | Heart injury | - |
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