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Characterization of Effector Memory CD8(+) T Cells in the Synovial Fluid of Rheumatoid Arthritis
DC Field | Value | Language |
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dc.contributor.author | Cho, Bon-A | - |
dc.contributor.author | Sim, Ji Hyun | - |
dc.contributor.author | Park, Ji Ah | - |
dc.contributor.author | Kim, Hye Won | - |
dc.contributor.author | Yoo, Wan-Hee | - |
dc.contributor.author | Lee, Seung-Hyun | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Kang, Jae Seung | - |
dc.contributor.author | Hwang, Young-Il | - |
dc.contributor.author | Lee, Wang Jae | - |
dc.contributor.author | Kang, Insoo | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.date.accessioned | 2024-05-16T01:32:54Z | - |
dc.date.available | 2024-05-16T01:32:54Z | - |
dc.date.created | 2021-11-26 | - |
dc.date.created | 2021-11-26 | - |
dc.date.created | 2021-11-26 | - |
dc.date.created | 2021-11-26 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Journal of Clinical Immunology, Vol.32 No.4, pp.709-720 | - |
dc.identifier.issn | 0271-9142 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202664 | - |
dc.description.abstract | Little is known about the cellular characteristics of CD8(+) T cells in rheumatoid arthritis (RA). We addressed this by investigating whether the frequency of the CD8(+) T cell subsets and their phenotypic characteristics are altered in the peripheral blood and synovial fluid (SF) from patients with RA. In this study, CD8(+) T cells, mainly CD45RA(-) effector memory (EM) CD8(+) T cells, were increased significantly in the SF, but not in the peripheral blood from RA patients, compared with healthy controls. The synovial EM CD8(+) T cells were activated phenotypes with high levels of CD80, CD86, and PD-1, and had a proliferating signature in vivo upon Ki-67 staining, whereas the Fas-positive cells were prone to apoptosis. In addition, EM CD8(+) T cells in the SF were less cytotoxic, as they expressed less perforin and granzyme B. In particular, the proportions of synovial fluid mononuclear cells that were CCR4(+)CD8(+) T cells and IL-4-producing CD8(+) T cells (i.e., Tc2 cells) were significantly higher than those in peripheral blood mononuclear cells of patients with RA and healthy controls. In addition, the number of IL-10-producing CD8(+) suppressor T (Ts) cells increased significantly in the SF of RA patients. Especially, CD8(+) T cells were inversely correlated with disease activity. These findings strongly suggest that EM CD8(+) T cells in the SF are increased, likely because of inflammation, and they may be involved in modulating inflammation, thereby affecting the development and progression of RA. | - |
dc.language | 영어 | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | Characterization of Effector Memory CD8(+) T Cells in the Synovial Fluid of Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10875-012-9674-3 | - |
dc.citation.journaltitle | Journal of Clinical Immunology | - |
dc.identifier.wosid | 000305981400008 | - |
dc.identifier.scopusid | 2-s2.0-84863986199 | - |
dc.citation.endpage | 720 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 709 | - |
dc.citation.volume | 32 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Sup | - |
dc.contributor.affiliatedAuthor | Kang, Jae Seung | - |
dc.contributor.affiliatedAuthor | Hwang, Young-Il | - |
dc.contributor.affiliatedAuthor | Lee, Wang Jae | - |
dc.contributor.affiliatedAuthor | Lee, Eun Bong | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | CHEMOKINE RECEPTORS | - |
dc.subject.keywordPlus | PSORIASIS-VULGARIS | - |
dc.subject.keywordPlus | CD28 EXPRESSION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | INTERLEUKIN-15 | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SYNOVIOCYTES | - |
dc.subject.keywordAuthor | Human CD8(+) Tcells | - |
dc.subject.keywordAuthor | effector memory cells | - |
dc.subject.keywordAuthor | type 2 CD8(+) Tcells | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
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