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Phenotypic Characterization of Peripheral T Cells and Their Dynamics in Scrub Typhus Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Bon-A | - |
dc.contributor.author | Ko, Youngho | - |
dc.contributor.author | Kim, Yeon-Sook | - |
dc.contributor.author | Kim, Sanguk | - |
dc.contributor.author | Choi, Myung-Sik | - |
dc.contributor.author | Kim, Ik-Sang | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Cho, Nam-Hyuk | - |
dc.date.accessioned | 2024-05-16T01:32:58Z | - |
dc.date.available | 2024-05-16T01:32:58Z | - |
dc.date.created | 2021-03-04 | - |
dc.date.created | 2021-03-04 | - |
dc.date.created | 2021-03-04 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | PLoS Neglected Tropical Diseases, Vol.6 No.8, p. e1789 | - |
dc.identifier.issn | 1935-2727 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202666 | - |
dc.description.abstract | Background: Scrub typhus, caused by Orientia tsutsugamushi infection, is one of the main causes of febrile illness in the Asia-Pacific region. Although cell-mediated immunity plays an important role in protection, little is known about the phenotypic changes and dynamics of leukocytes in scrub typhus patients. Methodology/Principal Findings: To reveal the underlying mechanisms of immunological pathogenesis, we extensively analyzed peripheral blood leukocytes, especially T cells, during acute and convalescent phases of infection in human patients and compared with healthy volunteers. We observed neutrophilia and CD4(+) T lymphopenia in the acute phase of infection, followed by proliferation of CD8(+) T cells during the convalescent phase. Massive T cell apoptosis was detected in the acute phase and preferential increase of CD8(+) T cells with activated phenotypes was observed in both acute and convalescent phases, which might be associated or correlated with elevated serum IL-7 and IL-15. Interestingly, peripheral Treg cells were significantly down-regulated throughout the disease course. Conclusions/Significance: The remarkable decrease of CD4(+) T cells, including Treg cells, during the acute phase of infection may contribute to the loss of immunological memory that are often observed in vaccine studies and recurrent human infection. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | Phenotypic Characterization of Peripheral T Cells and Their Dynamics in Scrub Typhus Patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pntd.0001789 | - |
dc.citation.journaltitle | PLoS Neglected Tropical Diseases | - |
dc.identifier.wosid | 000308497100025 | - |
dc.identifier.scopusid | 2-s2.0-84865988443 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | e1789 | - |
dc.citation.volume | 6 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Choi, Myung-Sik | - |
dc.contributor.affiliatedAuthor | Kim, Ik-Sang | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.contributor.affiliatedAuthor | Cho, Nam-Hyuk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ORIENTIA-TSUTSUGAMUSHI INFECTION | - |
dc.subject.keywordPlus | RICKETTSIA-TSUTSUGAMUSHI | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | CYNOMOLGUS MONKEYS | - |
dc.subject.keywordPlus | GAMMA-INTERFERON | - |
dc.subject.keywordPlus | CHEMOKINE GENES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CD8(+) | - |
dc.subject.keywordPlus | APOPTOSIS | - |
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