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Dual roles of IL-15 in maintaining IL-7RαlowCCR7 - memory CD8+ T cells in humans via recovering the phosphatidylinositol 3-kinase/AKT pathway : Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Hwang, Kyung-A | - |
dc.contributor.author | Kang, Insoo | - |
dc.date.accessioned | 2024-05-16T01:33:55Z | - |
dc.date.available | 2024-05-16T01:33:55Z | - |
dc.date.created | 2024-04-19 | - |
dc.date.created | 2024-04-19 | - |
dc.date.created | 2024-04-19 | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | Journal of Immunology, Vol.179 No.10, pp.6734-6740 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202696 | - |
dc.description.abstract | Recently, we identified two subsets of CCR7(-) memory CD8(+) T cells expressing high and low levels of the IL-7R alpha-chain (IL-7R alpha) that is essential for memory T cell survival in human peripheral blood. IL-7R alpha(low)CCR7(-) memory CD8(+) T cells that produce effector cytokines and perforin have impaired proliferation and survival in response to TCR triggering and IL-7, respectively. These findings raise a question of how such cells are sustained at significant numbers, > 20% of peripheral CD8(+) T cells, despite impaired IL-7- and TCR-mediated cell maintenance. In this study, we demonstrate that IL-7R alpha(low)CCR7(-) memory CD8(+) T cells have increased expression of IL-2/15R beta-chain (IL-2/15R beta 3), which is critical for IL-15 signaling, with enhanced gene expression of T box expressed in T cells (T-bet) and eomesodermin (eomes), transcriptional factors involved in IL-2/15R beta expression compared with IL-7R alpha(high)CCR7(-) memory CD8(+) T cells. Such a cytokine chain is functional as IL-7R alpha(low)CCR7(-) memory CD8(+) T cells proliferate considerably in response to IL-15. Furthermore, adding IL-15 to TCR'triggering recovers impaired TCR-mediated proliferation of IL-7R alpha(low) memory CD8(+) T cells via restoring the activation of the PI3K/AKT pathway. These findings indicate that IL-15 has dual roles in maintaining IL-7R alpha(low)CCR7(-) memory CD8(+) T cells via TCR-dependent and -independent mechanisms. Moreover, IL-15 can be useful in reviving impaired proliferative function of such memory CD8(+) T cells with effector functions against infections and tumors via rescuing the PI3K/AKT pathway. | - |
dc.language | 영어 | - |
dc.publisher | American Association of Immunologists | - |
dc.title | Dual roles of IL-15 in maintaining IL-7RαlowCCR7 - memory CD8+ T cells in humans via recovering the phosphatidylinositol 3-kinase/AKT pathway | - |
dc.title.alternative | Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.179.10.6734 | - |
dc.citation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | 000250792700041 | - |
dc.identifier.scopusid | 2-s2.0-38449103091 | - |
dc.citation.endpage | 6740 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 6734 | - |
dc.citation.volume | 179 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Rae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HOMEOSTATIC PROLIFERATION | - |
dc.subject.keywordPlus | IL-7R-ALPHA EXPRESSION | - |
dc.subject.keywordPlus | SERUM INTERLEUKIN-15 | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ABSENCE | - |
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