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Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs
DC Field | Value | Language |
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dc.contributor.author | Cho, Sung Yup | - |
dc.contributor.author | Lee, Seungun | - |
dc.contributor.author | Yeom, Jeonghun | - |
dc.contributor.author | Kim, Hyo-Jun | - |
dc.contributor.author | Lee, Jin-Haeng | - |
dc.contributor.author | Shin, Ji-Woong | - |
dc.contributor.author | Kwon, Mee-ae | - |
dc.contributor.author | Lee, Ki Baek | - |
dc.contributor.author | Jeong, Eui Man | - |
dc.contributor.author | Ahn, Hee Sung | - |
dc.contributor.author | Shin, Dong-Myung | - |
dc.contributor.author | Kim, Kyunggon | - |
dc.contributor.author | Kim, In Gyu | - |
dc.date.accessioned | 2024-05-16T01:38:43Z | - |
dc.date.available | 2024-05-16T01:38:43Z | - |
dc.date.created | 2020-05-19 | - |
dc.date.created | 2020-05-19 | - |
dc.date.created | 2020-05-19 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | Life Science Alliance, Vol.3 No.3, p. e201900565 | - |
dc.identifier.issn | 2575-1077 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202745 | - |
dc.description.abstract | Hypoxia selectively enhances mRNA translation despite suppressed mammalian target of rapamycin complex 1 activity, contributing to gene expression reprogramming that promotes metastasis and survival of cancer cells. Little is known about how this paradoxical control of translation occurs. Here, we report a new pathway that links hypoxia to selective mRNA translation. Transglutaminase 2 (TG2) is a hypoxia-inducible factor 1-inducible enzyme that alters the activity of substrate proteins by polyamination or crosslinking. Under hypoxic conditions, TG2 polyaminated eukaryotic translation initiation factor 4E (eIF4E)-bound eukaryotic translation initiation factor 4E-binding proteins (4EBPs) at conserved glutamine residues. 4EBP1 polyamination enhances binding affinity for Raptor, thereby increasing phosphorylation of 4EBP1 and cap-dependent translation. Proteomic analyses of newly synthesized proteins in hypoxic cells revealed that TG2 activity preferentially enhanced the translation of a subset of mRNA containing G/C-rich 5'UTRs but not upstream ORF or terminal oligopyrimidine motifs. These results indicate that TG2 is a critical regulator in hypoxia-induced selective mRNA translation and provide a promising molecular target for the treatment of cancers. | - |
dc.language | 영어 | - |
dc.publisher | Life Science Alliance LLC | - |
dc.title | Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs | - |
dc.type | Article | - |
dc.identifier.doi | 10.26508/lsa.201900565 | - |
dc.citation.journaltitle | Life Science Alliance | - |
dc.identifier.wosid | 000523303300005 | - |
dc.identifier.scopusid | 2-s2.0-85079737877 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | e201900565 | - |
dc.citation.volume | 3 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Sung Yup | - |
dc.contributor.affiliatedAuthor | Kim, In Gyu | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | TISSUE TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | CROSS-LINKING | - |
dc.subject.keywordPlus | EUKARYOTIC TRANSLATION | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
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