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Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
DC Field | Value | Language |
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dc.contributor.author | Lowes, Daniel C. | - |
dc.contributor.author | Chamberlin, Linda A. | - |
dc.contributor.author | Kretsge, Lisa N. | - |
dc.contributor.author | Holt, Emma S. | - |
dc.contributor.author | Abbas, Atheir, I | - |
dc.contributor.author | Park, Alan J. | - |
dc.contributor.author | Yusufova, Lyubov | - |
dc.contributor.author | Bretton, Zachary H. | - |
dc.contributor.author | Firdous, Ayesha | - |
dc.contributor.author | Enikolopov, Armen G. | - |
dc.contributor.author | Gordon, Joshua A. | - |
dc.contributor.author | Harris, Alexander Z. | - |
dc.date.accessioned | 2024-05-20T00:39:30Z | - |
dc.date.available | 2024-05-20T00:39:30Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, Vol.12 No.1 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203353 | - |
dc.description.abstract | Decreased pleasure-seeking (anhedonia) forms a core symptom of depression. Stressful experiences precipitate depression and disrupt reward-seeking, but it remains unclear how stress causes anhedonia. We recorded simultaneous neural activity across limbic brain areas as mice underwent stress and discovered a stress-induced 4Hz oscillation in the nucleus accumbens (NAc) that predicts the degree of subsequent blunted reward-seeking. Surprisingly, while previous studies on blunted reward-seeking focused on dopamine (DA) transmission from the ventral tegmental area (VTA) to the NAc, we found that VTA GABA, but not DA, neurons mediate stress-induced blunted reward-seeking. Inhibiting VTA GABA neurons disrupts stress-induced NAc oscillations and rescues reward-seeking. By contrast, mimicking this signature of stress by stimulating NAc-projecting VTA GABA neurons at 4Hz reproduces both oscillations and blunted reward-seeking. Finally, we find that stress disrupts VTA GABA, but not DA, neural encoding of reward anticipation. Thus, stress elicits VTA-NAc GABAergic activity that induces VTA GABA mediated blunted reward-seeking. Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice. | - |
dc.language | 영어 | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-021-23906-2 | - |
dc.citation.journaltitle | NATURE COMMUNICATIONS | - |
dc.identifier.wosid | 000663747800029 | - |
dc.identifier.scopusid | 2-s2.0-85107545470 | - |
dc.citation.number | 1 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Alan J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CHOLINERGIC INTERNEURONS | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | THETA OSCILLATIONS | - |
dc.subject.keywordPlus | DOPAMINE NEURONS | - |
dc.subject.keywordPlus | VTA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | ANHEDONIA | - |
dc.subject.keywordPlus | CIRCUITRY | - |
dc.subject.keywordPlus | SALIENCE | - |
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