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Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity
DC Field | Value | Language |
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dc.contributor.author | Park, Alan Jung | - |
dc.contributor.author | Shetty, Mahesh Shivarama | - |
dc.contributor.author | Baraban, Jay M. | - |
dc.contributor.author | Abel, Ted | - |
dc.date.accessioned | 2024-05-20T00:39:40Z | - |
dc.date.available | 2024-05-20T00:39:40Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | MOLECULAR BRAIN, Vol.13 No.1 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203356 | - |
dc.description.abstract | Activity-dependent local protein synthesis is critical for synapse-specific, persistent plasticity. Abnormalities in local protein synthesis have been implicated in psychiatric disorders. We have recently identified the translin/trax microRNA-degrading enzyme as a novel mediator of protein synthesis at activated synapses. Additionally, translin knockout (KO) mice, which lack translin/trax, exhibit some of the behavioral abnormalities found in a mouse model of fragile X syndrome (fragile X mental retardation protein-FMRP-KO mice). Therefore, identifying signaling pathways interacting with translin/trax to support persistent synaptic plasticity is a translationally relevant goal. Here, as a first step to achieve this goal, we have assessed the requirement of translin/trax for multiple hippocampal synaptic plasticity paradigms that rely on distinct molecular mechanisms. We found that mice lacking translin/trax exhibited selective impairment in a form of persistent hippocampal plasticity, which requires postsynaptic protein kinase A (PKA) activity. In contrast, enduring forms of plasticity that are dependent on presynaptic PKA were unaffected. Furthermore, these mice did not display exaggerated metabotropic glutamate receptor-mediated long-term synaptic depression (mGluR-LTD), a hallmark of the FMRP KO mice. On the contrary, translin KO mice exhibited deficits in N-methyl-d-aspartate receptor (NMDAR) dependent LTD, a phenotype not observed in the FMRP knockouts. Taken together, these findings demonstrate that translin/trax mediates long-term synaptic plasticity that is dependent on postsynaptic PKA signaling and suggest that translin/trax and FMRP play distinct roles in hippocampal synaptic plasticity. | - |
dc.language | 영어 | - |
dc.publisher | BMC | - |
dc.title | Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13041-020-00691-5 | - |
dc.citation.journaltitle | MOLECULAR BRAIN | - |
dc.identifier.wosid | 000593935600001 | - |
dc.identifier.scopusid | 2-s2.0-85095755555 | - |
dc.citation.number | 1 | - |
dc.citation.volume | 13 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Alan Jung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | D-ASPARTATE RECEPTOR | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | TRANSLATIONAL CONTROL | - |
dc.subject.keywordPlus | AKAP150-ANCHORED PKA | - |
dc.subject.keywordPlus | AREA CA1 | - |
dc.subject.keywordPlus | POTENTIATION | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | Translin | - |
dc.subject.keywordAuthor | Trax | - |
dc.subject.keywordAuthor | Long-term potentiation | - |
dc.subject.keywordAuthor | Long-term depression | - |
dc.subject.keywordAuthor | Local protein synthesis | - |
dc.subject.keywordAuthor | Hippocampal synaptic plasticity | - |
dc.subject.keywordAuthor | FMRP | - |
dc.subject.keywordAuthor | RNA-binding protein | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | PKA | - |
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