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Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Alan Jung | - |
dc.contributor.author | Havekes, Robbert | - |
dc.contributor.author | Fu, Xiuping | - |
dc.contributor.author | Hansen, Rolf | - |
dc.contributor.author | Tudor, Jennifer C. | - |
dc.contributor.author | Peixoto, Lucia | - |
dc.contributor.author | Li, Zhi | - |
dc.contributor.author | Wu, Yen-Ching | - |
dc.contributor.author | Poplawski, Shane G. | - |
dc.contributor.author | Baraban, Jay M. | - |
dc.contributor.author | Abel, Ted | - |
dc.date.accessioned | 2024-05-20T00:40:49Z | - |
dc.date.available | 2024-05-20T00:40:49Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | ELIFE, Vol.6 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | https://hdl.handle.net/10371/203377 | - |
dc.description.abstract | Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. Yet, how learning triggers this process to form memory is unclear. Translin/trax is a candidate to drive this learning-induced memory mechanism by suppressing microRNA-mediated translational silencing at activated synapses. We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term memory. Hippocampal samples harvested from these mice following learning show increases in several disease-related microRNAs targeting the activin A receptor type 1C (ACVR1C), a component of the transforming growth factor-beta receptor superfamily. Furthermore, the absence of translin/trax abolishes synaptic upregulation of ACVR1C protein after learning. Finally, synaptic tagging and long-term memory deficits in mice lacking translin/trax are mimicked by ACVR1C inhibition. Thus, we define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax. | - |
dc.language | 영어 | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.title | Learning induces the translin/trax RNase complex to express activin receptors for persistent memory | - |
dc.type | Article | - |
dc.identifier.doi | 10.7554/eLife.27872 | - |
dc.citation.journaltitle | ELIFE | - |
dc.identifier.wosid | 000411197700001 | - |
dc.identifier.scopusid | 2-s2.0-85032990370 | - |
dc.citation.volume | 6 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Alan Jung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | TESTIS-BRAIN | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | CAPTURE HYPOTHESIS | - |
dc.subject.keywordPlus | DEPENDENT MEMORY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | RISC ACTIVATION | - |
dc.subject.keywordPlus | MICE | - |
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