Publications

Detailed Information

PKA anchoring and synaptic tagging and capture

Cited 0 time in Web of Science Cited 2 time in Scopus
Authors

Park, Alan Jung; Abel, Ted

Issue Date
2015
Publisher
Springer New York
Citation
Synaptic Tagging and Capture: From Synapses to Behavior, pp.61-78
Abstract
Synaptic tagging and capture (STC) hypothesis has been receiving increasing attention because it refl ects heterosynaptic association of information processing during memory formation in the brain. Indeed, electrophysiological and behavioral studies suggest that STC is a better cellular model for memory formation than the conventional homosynaptic experiment. In STC, a short-lasting potentiation in one pathway becomes persistent when it is paired with a long-lasting potentiation in the other independent pathway. It has been proposed that the setting of synapse-specific tag and capture of non-synapse-specific diffusible gene products by the tag determines the fate of each pathway. However, the mechanism of STC is still elusive and three major questions should be answered: (1) What is the tag and how does it modulate synapse-specific plasticity? (2) How does the tag capture gene products? (3) What are the gene products and how are they produced? Although several molecules and processes have been suggested to answer to these questions, they only provide partial explanations about the phenomenon. Here, this article will discuss how PKA modulates synapse-specifi c neuronal processing by coordinating signaling molecules and processes through PKA anchoring proteins, and how anchored PKA is involved in the generation and capture of plasticity-related gene products. Having PKA as a key molecule, the goal of this article is to provide a unified model of STC that addresses the key questions.
URI
https://hdl.handle.net/10371/203397
DOI
https://doi.org/10.1007/978-1-4939-1761-7_5
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Medicine
Research Area Computational decoding, Electrophysiology, Neuroscience

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share