Publications
Detailed Information
Gravin Orchestrates Protein Kinase A and β2-Adrenergic Receptor Signaling Critical for Synaptic Plasticity and Memory
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Havekes, Robbert | - |
dc.contributor.author | Canton, David A. | - |
dc.contributor.author | Park, Alan J. | - |
dc.contributor.author | Huang, Ted | - |
dc.contributor.author | Nie, Ting | - |
dc.contributor.author | Day, Jonathan P. | - |
dc.contributor.author | Guercio, Leonardo A. | - |
dc.contributor.author | Grimes, Quinn | - |
dc.contributor.author | Luczak, Vincent | - |
dc.contributor.author | Gelman, Irwin H. | - |
dc.contributor.author | Baillie, George S. | - |
dc.contributor.author | Scott, John D. | - |
dc.contributor.author | Abel, Ted | - |
dc.date.accessioned | 2024-05-20T00:42:48Z | - |
dc.date.available | 2024-05-20T00:42:48Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE, Vol.32 No.50, pp.18137-18149 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203413 | - |
dc.description.abstract | A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes important for long-lasting forms of synaptic plasticity and memory storage. In the forebrain, the anchoring protein gravin recruits a signaling complex containing PKA, PKC, calmodulin, and PDE4D (phosphodiesterase 4D) to the beta 2-adrenergic receptor. Here, we show that mice lacking the alpha-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasticity including beta 2-adrenergic receptor-mediated plasticity, and selective impairments of long-term memory storage. Furthermore, both hippocampal beta 2-adrenergic receptor phosphorylation by PKA, and learning-induced activation of ERK in the CA1 region of the hippocampus are attenuated in mice lacking gravin-alpha. We conclude that gravin compartmentalizes a significant pool of PKA that regulates learning-induced beta 2-adrenergic receptor signaling and ERK activation in the hippocampus in vivo, thereby organizing molecular interactions between glutamatergic and noradrenergic signaling pathways for long-lasting synaptic plasticity, and memory storage. | - |
dc.language | 영어 | - |
dc.publisher | SOC NEUROSCIENCE | - |
dc.title | Gravin Orchestrates Protein Kinase A and β2-Adrenergic Receptor Signaling Critical for Synaptic Plasticity and Memory | - |
dc.type | Article | - |
dc.identifier.doi | 10.1523/JNEUROSCI.3612-12.2012 | - |
dc.citation.journaltitle | JOURNAL OF NEUROSCIENCE | - |
dc.identifier.wosid | 000312404700020 | - |
dc.identifier.scopusid | 2-s2.0-84870995899 | - |
dc.citation.endpage | 18149 | - |
dc.citation.number | 50 | - |
dc.citation.startpage | 18137 | - |
dc.citation.volume | 32 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Alan J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | Y-MAZE TASK | - |
dc.subject.keywordPlus | BETA-ADRENERGIC-RECEPTORS | - |
dc.subject.keywordPlus | BETA(2)-ADRENERGIC RECEPTOR | - |
dc.subject.keywordPlus | SPATIAL MEMORY | - |
dc.subject.keywordPlus | ANCHORING PROTEINS | - |
dc.subject.keywordPlus | NUCLEAR TRANSLOCATION | - |
dc.subject.keywordPlus | HIPPOCAMPAL-LESIONS | - |
dc.subject.keywordPlus | OBJECT RECOGNITION | - |
dc.subject.keywordPlus | CONTEXTUAL MEMORY | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.