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Microfabricated platforms to modulate and monitor T cell synapse assembly
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Hong-Ryul | - |
dc.contributor.author | Choi, Jong-Cheol | - |
dc.contributor.author | Cho, Wonhwa | - |
dc.contributor.author | Doh, Junsang | - |
dc.date.accessioned | 2024-05-20T06:14:32Z | - |
dc.date.available | 2024-05-20T06:14:32Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, Vol.5 No.1, pp.67-74 | - |
dc.identifier.issn | 1939-0041 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203486 | - |
dc.description.abstract | Immunological synapse (IS) is a complex supramolecular structure formed at the interface between T cells and antigen presenting cells (APCs) during T cell antigen recognition. Microfabricated platforms have made great contributions to our understanding of the assembly dynamics and functional roles of the T cell synapses over the last decade. Here, we review three different types of microfabricated platforms developed to modulate andmonitor the T cell synapse assembly. Firstly, multi-protein micropatterned surfaces presenting key ligands for T cell activation that can modulate the spatial distribution of receptors/signaling molecules in T cell synapses are described. Secondly, micropatterned supported bilayers that can modulate the dynamics of T cell receptor (TCR) microclusters are introduced. Lastly, T-APC pair arrays that allow for improved fluorescence live cell imaging are discussed. (C) 2012 Wiley Periodicals, Inc. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Microfabricated platforms to modulate and monitor T cell synapse assembly | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/wnan.1182 | - |
dc.citation.journaltitle | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology | - |
dc.identifier.wosid | 000314987200005 | - |
dc.identifier.scopusid | 2-s2.0-84871668163 | - |
dc.citation.endpage | 74 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 67 | - |
dc.citation.volume | 5 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SUPRAMOLECULAR ACTIVATION CLUSTER | - |
dc.subject.keywordPlus | KINASE-C-THETA | - |
dc.subject.keywordPlus | IMMUNOLOGICAL SYNAPSE | - |
dc.subject.keywordPlus | ANTIGEN RECEPTOR | - |
dc.subject.keywordPlus | SIGNALING MOLECULES | - |
dc.subject.keywordPlus | LIGAND RECOGNITION | - |
dc.subject.keywordPlus | MICROCLUSTERS | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | BILAYERS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
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