Publications
Detailed Information
Microfabricated platforms to modulate and monitor T cell synapse assembly
Cited 6 time in
Web of Science
Cited 7 time in Scopus
- Authors
- Issue Date
- 2013-01
- Publisher
- John Wiley & Sons Inc.
- Citation
- Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, Vol.5 No.1, pp.67-74
- Abstract
- Immunological synapse (IS) is a complex supramolecular structure formed at the interface between T cells and antigen presenting cells (APCs) during T cell antigen recognition. Microfabricated platforms have made great contributions to our understanding of the assembly dynamics and functional roles of the T cell synapses over the last decade. Here, we review three different types of microfabricated platforms developed to modulate andmonitor the T cell synapse assembly. Firstly, multi-protein micropatterned surfaces presenting key ligands for T cell activation that can modulate the spatial distribution of receptors/signaling molecules in T cell synapses are described. Secondly, micropatterned supported bilayers that can modulate the dynamics of T cell receptor (TCR) microclusters are introduced. Lastly, T-APC pair arrays that allow for improved fluorescence live cell imaging are discussed. (C) 2012 Wiley Periodicals, Inc.
- ISSN
- 1939-0041
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.