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An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts

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dc.contributor.authorCho, Sung Yup-
dc.contributor.authorKang, Wonyoung-
dc.contributor.authorHan, Jee Yun-
dc.contributor.authorMin, Seoyeon-
dc.contributor.authorKang, Jinjoo-
dc.contributor.authorLee, Ahra-
dc.contributor.authorKwon, Jee Young-
dc.contributor.authorLee, Charles-
dc.contributor.authorPark, Hansoo-
dc.date.accessioned2024-05-20T07:28:54Z-
dc.date.available2024-05-20T07:28:54Z-
dc.date.created2024-05-20-
dc.date.issued2016-02-
dc.identifier.citationMolecules and Cells, Vol.39 No.2, pp.77-86-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://hdl.handle.net/10371/203517-
dc.description.abstractCancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes. Despite recent advances in high-throughput sequencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies. Patient-derived xenografts (PDX), which are established by the transfer of patient tumors into immunodeficient mice, serve as a platform for co-clinical trials by enabling the integration of clinical data, genomic profiles, and drug responsiveness data to determine precisely targeted therapies. PDX models retain many of the key characteristics of patients' tumors including histology, genomic signature, cellular heterogeneity, and drug responsiveness. These models can also be applied to the development of biomarkers for drug responsiveness and personalized drug selection. This review summarizes our current knowledge of this field, including methodologic aspects, applications in drug development, challenges and limitations, and utilization for precision cancer medicine.-
dc.language영어-
dc.publisher한국분자세포생물학회-
dc.titleAn Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts-
dc.typeArticle-
dc.identifier.doi10.14348/molcells.2016.2350-
dc.citation.journaltitleMolecules and Cells-
dc.identifier.wosid000371264600001-
dc.identifier.scopusid2-s2.0-84965180936-
dc.citation.endpage86-
dc.citation.number2-
dc.citation.startpage77-
dc.citation.volume39-
dc.identifier.kciidART002079777-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorCho, Sung Yup-
dc.type.docTypeReview-
dc.description.journalClass1-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusTUMOR XENOGRAFTS-
dc.subject.keywordPlusMOLECULAR CHARACTERIZATION-
dc.subject.keywordPlusORTHOTOPIC XENOGRAFTS-
dc.subject.keywordPlusPANCREATIC-CANCER-
dc.subject.keywordPlusNAB-PACLITAXEL-
dc.subject.keywordPlusLUNG CANCERS-
dc.subject.keywordPlusMOUSE MODELS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusGLIOBLASTOMA-
dc.subject.keywordAuthorcancer drug development-
dc.subject.keywordAuthorcancer genomics-
dc.subject.keywordAuthorpatient-derived xenografts-
dc.subject.keywordAuthorprecision medicine-
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  • College of Medicine
Research Area Cancer genomics, Drug resistance, Targeted therapeutics

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