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Visual detection of odorant geraniol enabled by integration of a human olfactory receptor into polydiacetylene/lipid nano-assembly
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Taegon | - |
dc.contributor.author | Moon, Dongseok | - |
dc.contributor.author | Park, Jin Hyuk | - |
dc.contributor.author | Yang, Heehong | - |
dc.contributor.author | Cho, Seongyeon | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Ahn, Dong June | - |
dc.date.accessioned | 2024-05-27T08:45:40Z | - |
dc.date.available | 2024-05-27T08:45:40Z | - |
dc.date.created | 2020-03-26 | - |
dc.date.issued | 2019-04-28 | - |
dc.identifier.citation | Nanoscale, Vol.11 No.16, pp.7582-7587 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203799 | - |
dc.description.abstract | A new polydiacetylene lipid/human olfactory receptor nano-assembly was fabricated for the visual detection of an odorant for the first time. The assembly consisted of phospholipid-mixed polydiacetylenes (PDAs) and human olfactory receptors (hORs) in detergent micelles. To overcome the limitations of bioelectronic noses, hOR-embedded chromatic complexes (PDA/hORs) were developed, introducing PDAs that showed color and fluorescence transitions against various stimuli. The chromatic nanocomplexes reacted with target molecules, showing a fluorescence intensity increase in a dose-dependent manner and target selectivity among various odorants. As a result, a color transition of the assembly from blue to purple occurred, allowing the visual detection of the odorant geraniol. Through circular dichroism (CD) spectroscopy and a tryptophan fluorescence quenching method, the structural and functional properties of the hORs embedded in the complexes were confirmed. Based on this first work, future array devices, integrating multiple nano-assemblies, can be substantiated and utilized in environmental assessment and analysis of food quality. | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Visual detection of odorant geraniol enabled by integration of a human olfactory receptor into polydiacetylene/lipid nano-assembly | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c9nr00249a | - |
dc.citation.journaltitle | Nanoscale | - |
dc.identifier.wosid | 000467776400005 | - |
dc.identifier.scopusid | 2-s2.0-85065110059 | - |
dc.citation.endpage | 7587 | - |
dc.citation.number | 16 | - |
dc.citation.startpage | 7582 | - |
dc.citation.volume | 11 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Tai Hyun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BIOELECTRONIC NOSE | - |
dc.subject.keywordPlus | RATIONAL DESIGN | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | FILMS | - |
dc.subject.keywordPlus | SUPRAMOLECULES | - |
dc.subject.keywordPlus | RECONSTITUTION | - |
dc.subject.keywordPlus | TRYPTOPHAN | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | COLOR | - |
dc.subject.keywordPlus | ASSAY | - |
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