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IL-10-induced modulation of macrophage polarization suppresses outer-blood-retinal barrier disruption in the streptozotocin-induced early diabetic retinopathy mouse model
DC Field | Value | Language |
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dc.contributor.author | Lee, Seok Jae | - |
dc.contributor.author | Noh, Sung-Eun | - |
dc.contributor.author | Jo, Dong Hyun | - |
dc.contributor.author | Cho, Chang Sik | - |
dc.contributor.author | Park, Kyu-Sang | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.date.accessioned | 2024-06-04T04:27:19Z | - |
dc.date.available | 2024-06-04T04:27:19Z | - |
dc.date.created | 2024-05-23 | - |
dc.date.issued | 2024-05 | - |
dc.identifier.citation | FASEB Journal, Vol.38 No.9, p. e23638 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204207 | - |
dc.description.abstract | Diabetic retinopathy (DR) is associated with ocular inflammation leading to retinal barrier breakdown, vascular leakage, macular edema, and vision loss. DR is not only a microvascular disease but also involves retinal neurodegeneration, demonstrating that pathological changes associated with neuroinflammation precede microvascular injury in early DR. Macrophage activation plays a central role in neuroinflammation. During DR, the inflammatory response depends on the polarization of retinal macrophages, triggering pro-inflammatory (M1) or anti-inflammatory (M2) activity. This study aimed to determine the role of macrophages in vascular leakage through the tight junction complexes of retinal pigment epithelium, which is the outer blood-retinal barrier (BRB). Furthermore, we aimed to assess whether interleukin-10 (IL-10), a representative M2-inducer, can decrease inflammatory macrophages and alleviate outer-BRB disruption. We found that modulation of macrophage polarization affects the structural and functional integrity of ARPE-19 cells in a co-culture system under high-glucose conditions. Furthermore, we demonstrated that intravitreal IL-10 injection induces an increase in the ratio of anti-inflammatory macrophages and effectively suppresses outer-BRB disruption and vascular leakage in a mouse model of early-stage streptozotocin-induced diabetes. Our results suggest that modulation of macrophage polarization by IL-10 administration during early-stage DR has a promising protective effect against outer-BRB disruption and vascular leakage. This finding provides valuable insights for early intervention in DR. | - |
dc.language | 영어 | - |
dc.publisher | Federation of American Societies for Experimental Biology | - |
dc.title | IL-10-induced modulation of macrophage polarization suppresses outer-blood-retinal barrier disruption in the streptozotocin-induced early diabetic retinopathy mouse model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1096/fj.202400053R | - |
dc.citation.journaltitle | FASEB Journal | - |
dc.identifier.wosid | 001215033600001 | - |
dc.identifier.scopusid | 2-s2.0-85192250136 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | e23638 | - |
dc.citation.volume | 38 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jo, Dong Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TOMOGRAPHIC HYPERREFLECTIVE FOCI | - |
dc.subject.keywordPlus | MACULAR EDEMA | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | VASCULAR LEAKAGE | - |
dc.subject.keywordPlus | NOMENCLATURE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | DETACHMENT | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | diabetic retinopathy | - |
dc.subject.keywordAuthor | IL-10 | - |
dc.subject.keywordAuthor | macrophage polarization | - |
dc.subject.keywordAuthor | outer blood-retinal barrier disruption | - |
dc.subject.keywordAuthor | streptozotocin-induced diabetic mouse model | - |
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